Serum Trans-Fatty Acid Concentration Is Elevated in Young Patients With Coronary Artery Disease in Japan.

Abstract

BACKGROUND:

Adverse effects of dietary intake of trans-fatty acids (TFA) on the incidence of coronary artery disease (CAD) are well recognized in Western countries. The risk of TFA, however, has not been well clarified in Japan. We investigated the association of serum TFA concentration with serum lipid profile, coronary risk factors, and prevalence of CAD.

METHODS AND RESULTS:

A total of 902 patients, who were hospitalized at Kobe University Hospital from July 2008 to March 2012 and gave written informed consent, were enrolled in this study. Among them, 463 patients had CAD, and 318 patients had metabolic syndrome (MetS). Serum TFA, elaidic acid (trans-9-C18:1) and linolelaidic acid (trans-9, 12-C18:2), were measured on gas chromatography/mass spectrometry. Serum TFA level had a positive correlation with body mass index, waist circumference, low-density lipoprotein cholesterol, triglycerides, and apolipoprotein B48, and an inverse correlation with age and high-density lipoprotein cholesterol. Fasting serum TFA, by age quartile in the young generation with CAD and/or MetS, was higher than that in patients without CAD and/or MetS. On multivariate logistic regression, TFA was identified as a CAD risk after adjustment for classical risk factors.

CONCLUSIONS:

Serum TFA concentration was elevated in young patients with CAD and/or MetS. Diet-derived TFA may cause a serious health problem, particularly in the young generation in Japan.

• Authors: Kenta Mori, Tatsuro Ishida, Tomoyuki Yasuda, Minoru Hasokawa, Tomoko Monguchi, Maki Sasaki, Kensuke Kondo, Hideto Nakajima, Masakazu Shinohara, Toshiro Shinke, Yasuhiro Irino, Ryuji Toh, Kunihiro Nishimura, Ken-Ichi Hirata
• Journal: Circulation journal : official journal of the Japanese Circulation Society (Circ J) Vol. 79 Issue 9 Pg. 2017-25 ( 2015) ISSN: 1347-4820 [Electronic] Japan
• PMID: 26166015 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cholesterol, HDL
• Dietary Fats
• Oleic Acids
• Trans Fatty Acids
• Oleic Acid
• elaidic acid

Topics

• Age Factors
• Aged
• Cholesterol, HDL (blood)
• Coronary Artery Disease (blood, chemically induced, epidemiology)
• Dietary Fats (adverse effects)
• Female
• Humans
• Incidence
• Japan (epidemiology)
• Male
• Metabolic Syndrome (blood, chemically induced, epidemiology)
• Middle Aged
• Oleic Acid (blood)
• Oleic Acids
• Prevalence
• Trans Fatty Acids (blood)