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Efficacy of Tocilizumab in the treatment of Eosinophilic fasciitis: Report of one case.

Abstract
A 43-year-old man was diagnosed with an Eosinophilic fasciitis with cutaneous and articular involvement. The patient experienced an early response with high-dose corticosteroids achieving a global remission of disease. Nevertheless, during the steroids tapering phase, he presented a new flare and subsequently developed a corticosteroid refractory disease. The addition of Methotrexate in monotherapy then associated with an anti-tumor necrosis factor agent did not show any additional benefit. Therefore Tocilizumab, a humanized monoclonal antibody against the interleukin-6 receptor, was initiated achieving an immediate response that persists after 36 months of follow-up. The use of this biological agent allows prednisone withdrawal at 3 months and remission of both articular and cutaneous manifestations at 6 months. This report describes for the first time the efficacy of an anti interleukin-6 agent in Eosinophilic fasciitis treatment.
AuthorsFrancisco Espinoza, Christian Jorgensen, Yves-Marie Pers
JournalJoint bone spine (Joint Bone Spine) Vol. 82 Issue 6 Pg. 460-1 (Dec 2015) ISSN: 1778-7254 [Electronic] France
PMID26162635 (Publication Type: Case Reports, Journal Article)
CopyrightCopyright © 2015 Société française de rhumatologie. Published by Elsevier SAS. All rights reserved.
Chemical References
  • Anti-Inflammatory Agents
  • Antibodies, Monoclonal, Humanized
  • IL6 protein, human
  • Interleukin-6
  • tocilizumab
Topics
  • Adult
  • Anti-Inflammatory Agents (therapeutic use)
  • Antibodies, Monoclonal, Humanized (therapeutic use)
  • Eosinophilia (diagnosis, drug therapy)
  • Fasciitis (diagnosis, drug therapy)
  • Humans
  • Interleukin-6 (antagonists & inhibitors)
  • Male
  • Treatment Outcome

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