Anakinra Hepatotoxicity in a Patient With Adult-Onset Still's Disease.

Abstract

We report a 46-year-old white woman with adult-onset Still's disease (AOSD) treated with anakinra, a IL-1B receptor antagonist. Within weeks, her liver enzymes deteriorated; subsequent cessation and rechallenge confirmed anakinra-related drug-induced liver injury (DILI). Although AOSD has been associated with liver involvement, little is known about the hepatotoxicity of anakinra. Heightened awareness by gastroenterologists and hepatologists is warranted.

• Authors: Osman Ahmed, Mayur Brahmania, Majid Alsahafi, Saad Alkhowaiter, Sig Erb
• Journal: ACG case reports journal (ACG Case Rep J) Vol. 2 Issue 3 Pg. 173-4 (Apr 2015) ISSN: 2326-3253 [Print] United States
• PMID: 26157954 (Publication Type: Case Reports)