Abstract | BACKGROUND:
Chemotherapy induced neuropathy pain remains as a major dose limiting side effect of many commonly used chemotherapeutic drugs. Presently newer antiepileptic agents have been developed with improved safety and tolerability profiles in alleviating neuropathic pain. OBJECTIVES: MATERIALS AND METHODS: RESULTS: In Radiant heat method, gabapentin and pregabalin treated animals found to have significant increase in the tail latency period compared to control and paclitaxel treated groups in all periods of observation. Acetone drop test and tail immersion test also showed significant response similar to Radiant heat method. Pregabalin showed highly significant effect when compared to gabapentin group. CONCLUSION: Both gabapentin and pregabalin produced significant anti-hyperalgesic and anti-allodynic effects in experimental animal models. Pregabalin treated group showed highly significant effect compared to gabapentin treated animals.
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Authors | A Mangaiarkkarasi, S Rameshkannan, R Meher Ali |
Journal | Journal of clinical and diagnostic research : JCDR
(J Clin Diagn Res)
Vol. 9
Issue 5
Pg. FF11-4
(May 2015)
ISSN: 2249-782X [Print] India |
PMID | 26155495
(Publication Type: Journal Article)
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