Abstract | PURPOSE: To assess the joint symptoms and the impact on patients' health-related quality of life (HRQOL) due to 5 years of anastrozole from the baseline data in the N-SAS BC 05 trial, a randomized clinical trial was designed to assess the efficacy of 5 additional years of anastrozole among women with breast cancer. METHODS: Joint symptoms and HRQOL were evaluated using an original questionnaire for joint symptoms, the Short Form 36-item Health Survey (SF-36), the EuroQol EQ-5D-3L, and a subscale of the Functional Assessment of Cancer Therapy-Endocrine Symptoms (FACT-ES). RESULTS: Baseline joint symptom and HRQOL data were collected from 330 patients between November 2007 and March 2010. Joint pain and joint stiffness were reported by 61.6 and 59.1 % of patients, respectively, although these symptoms did not affect the activities of daily living in 96.0 and 97.9 % of patients, respectively. Joint pain was reported in the knee by 61.0 % of patients and in the hand by 36.0 % of patients. Joint stiffness mainly affected the hand (67.9 %), especially the proximal interphalangeal joint, and typically occurred upon waking up or in the morning. Most SF-36 domains had good average scores, although slight decreases in physical functioning and role-physical were observed (compared to the national standard scores). The mean EQ-5D utility score was 0.86, and the total FACT-ES subscale score was 62.2/76. CONCLUSIONS: After 5 years of anastrozole, many of the patients reported joint pain and stiffness in mainly the hand and knee with mild symptoms and good HRQOL.
|
Authors | Hiroshi Yagata, Hiroshi Ohtsu, Yoshifumi Komoike, Shigehira Saji, Hiroyuki Takei, Toshitaka Nakamura, Yasuo Ohashi, Takuya Iwase, Kojiro Shimozuma |
Journal | Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer
(Support Care Cancer)
Vol. 24
Issue 2
Pg. 683-689
(Feb 2016)
ISSN: 1433-7339 [Electronic] Germany |
PMID | 26153513
(Publication Type: Journal Article, Multicenter Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Antineoplastic Agents, Hormonal
- Nitriles
- Triazoles
- Anastrozole
|
Topics |
- Activities of Daily Living
- Aged
- Aged, 80 and over
- Anastrozole
- Antineoplastic Agents, Hormonal
(administration & dosage, adverse effects)
- Breast Neoplasms
(drug therapy)
- Drug Administration Schedule
- Female
- Humans
- Joint Diseases
(chemically induced)
- Middle Aged
- Nitriles
(administration & dosage, adverse effects)
- Postmenopause
- Quality of Life
- Surveys and Questionnaires
- Treatment Outcome
- Triazoles
(administration & dosage, adverse effects)
|