Abstract | PURPOSE OF INVESTIGATION: To compare the efficacy and safety of two different second-generation ablation devices, Novasure impedance control system and microwave endometrial ablation (MEA), in cases of abnormal uterine bleeding (AUB). MATERIALS AND METHODS: This is a randomized controlled trial that took place in a single Gynecological Department of a University Hospital. Sixty-six women with dysfunctional uterine bleeding (DUB), unresponsive to medical treatment, were included in the trial. The ratio of women allocated to bipolar radio-frequency ablation or MEA was 1:1. Follow-up assessments were carried out at three and 12 months post-ablation. The present main outcome measure was amenorrhea rates 12-months post-treatment. RESULTS: The rate of amenorrhea at 12-months post-ablation was significantly higher in women treated by Novasure (25/33; 75.8%) as compared to those treated by MEA (8/33; 24.2%) (rate difference: +51.5%, 95% CI: +27.8 to +67.7). CONCLUSION: In women with DUB, endometrial ablation with Novasure bipolar radiofrequency impedance-controlled system is associated with increased rates of amenorrhea at 12-months post-treatment as compared to the MEA method.
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Authors | D Athanatos, G Pados, C A Venetis, P Stamatopoulos, D Rousso, D Tsolakidis, C P Stamatopoulos, B C Tarlatzis |
Journal | Clinical and experimental obstetrics & gynecology
(Clin Exp Obstet Gynecol)
Vol. 42
Issue 3
Pg. 347-51
( 2015)
ISSN: 0390-6663 [Print] Singapore |
PMID | 26152008
(Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial)
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Topics |
- Adult
- Amenorrhea
- Catheter Ablation
(methods)
- Double-Blind Method
- Electric Impedance
(therapeutic use)
- Endometrial Ablation Techniques
- Female
- Humans
- Menorrhagia
(surgery)
- Metrorrhagia
(surgery)
- Microwaves
(therapeutic use)
- Middle Aged
- Treatment Outcome
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