Abstract |
Recently, photothermal therapy (PTT) that utilizes photothermal conversion (PTC) agents to ablate cancer under near-infrared (NIR) irradiation has attracted a growing amount of attention because of its excellent therapeutic efficacy and improved target selectivity. Therefore, exploring novel PTC agents with an outstanding photothermal effect is a current research focus. Herein, we reported a polydopamine-coated magnetic composite particle with an enhanced PTC effect, which was synthesized simply through coating polydopamine (PDA) on the surface of magnetic Fe3O4 particles. Compared with magnetic Fe3O4 particles and PDA nanospheres, the core-shell nanomaterials exhibited an increased NIR absorption, and thus, an enhanced photothermal effect was obtained. We demonstrated the in vitro and in vivo effects of the photothermal therapy using our composite particles and their ability as a contrast agent in the T2-weighted magnetic resonance imaging. These results indicated that the multifunctional composite particles with enhanced photothermal effect are superior to magnetic Fe3O4 particles and PDA nanospheres alone.
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Authors | Rui Zheng, Sheng Wang, Ye Tian, Xinguo Jiang, Deliang Fu, Shun Shen, Wuli Yang |
Journal | ACS applied materials & interfaces
(ACS Appl Mater Interfaces)
Vol. 7
Issue 29
Pg. 15876-84
(Jul 29 2015)
ISSN: 1944-8252 [Electronic] United States |
PMID | 26151502
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Coated Materials, Biocompatible
- Contrast Media
- Indoles
- Magnetite Nanoparticles
- Photosensitizing Agents
- Polymers
- polydopamine
- Ferrosoferric Oxide
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Topics |
- Animals
- Cell Survival
(drug effects, radiation effects)
- Coated Materials, Biocompatible
(chemical synthesis)
- Contrast Media
(chemical synthesis)
- Ferrosoferric Oxide
(chemistry)
- Indoles
(chemistry, therapeutic use)
- Light
- Magnetic Resonance Imaging
(methods)
- Magnetite Nanoparticles
(chemistry, therapeutic use, ultrastructure)
- Male
- Materials Testing
- Mice
- Mice, Inbred BALB C
- Nanocomposites
(chemistry, ultrastructure)
- Neoplasms, Experimental
(drug therapy, pathology)
- Particle Size
- Photochemotherapy
(methods)
- Photosensitizing Agents
(chemical synthesis, therapeutic use)
- Polymers
(chemistry, therapeutic use)
- Theranostic Nanomedicine
(methods)
- Treatment Outcome
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