Abstract | BACKGROUND: OBJECTIVES: MATERIALS AND METHODS: Thirty-five newly diagnosed breast cancer patients were involved in this study from the Radiation Isotopes Center Khartoum (RICK) compared to 18 age- and sex-matched control subjects. Intravenous blood sample was obtained from each study subject and Enzyme Linked Immuno Sorbent Assay (ELISA) technique was used to determine the concentration of the two antibodies. RESULTS: Regarding the ANA concentration in the patients; the range was 0.7-1.8 IU/ml, mean was 0.96, and the standard deviation (SD) was 0.25; while the range of the concentration in the control subjects was 0.3-0.6 IU/ml, mean was 0.47, and SD was 0.07. However, when the means of patients and controls were compared, the difference was significant (P < 0.000). Concerning the result anti- double stranded DNA (anti-dsDNA), its concentration range in the patients was 2.6-151.9 IU/ml, the mean was 55.2, and SD was 25.6, while in healthy people concentration range was 26.1-97.3 IU/ml, the mean was 50.3, and SD was 16.9. There was no significant change between the patients and controls (P = 0.46). CONCLUSION: The ANA concentration in the patients was significantly increased, while there was no significant difference between the results of ADSDAs in the patients and the control subjects.
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Authors | Mohammed Elimam Ahamed Mohammed, Khalid Abdelhafiz |
Journal | Journal of cancer research and therapeutics
(J Cancer Res Ther)
2015 Apr-Jun
Vol. 11
Issue 2
Pg. 341-4
ISSN: 1998-4138 [Electronic] India |
PMID | 26148597
(Publication Type: Journal Article)
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Chemical References |
- Antibodies, Antinuclear
- Autoantibodies
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Topics |
- Adult
- Aged
- Antibodies, Antinuclear
(blood, immunology)
- Autoantibodies
(blood, immunology)
- Breast Neoplasms
(blood, immunology, pathology)
- Case-Control Studies
- Enzyme-Linked Immunosorbent Assay
- Female
- Humans
- Middle Aged
- Neoplasm Grading
- Neoplasm Staging
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