RECK Gene Polymorphism is Associated with Susceptibility and Prognosis of Wilms' Tumor in Chinese Children.

Abstract

BACKGROUND:

Wilms' tumor (WT) is the most common malignant renal tumor in children. Previous studies suggested the reversion-inducing, cysteine-rich protein with Kazal motifs (RECK) down-regulation might have a role in numerous human cancers. The current study was done to investigate the associations of RECK single-nucleotide polymorphisms (SNPs) with the WT susceptibility in Chinese children.

MATERIAL AND METHODS:

We analyzed 2 SNPs (rs10972727 and rs11788747) in a total of 97 WT children and 194 healthy matched controls (1:2 ratio) by real-time PCR and PCR-RFLP genotyping analysis.

RESULTS:

We found that the G allele of rs11788747 in the RECK gene was significantly associated with WT in Chinese children (OR=0.7, 95% CI: 0.45-0.99; P=0.042); as with another SNP rs10972727, however, no statistically significant difference was detected. Further analysis showed there was also a statistically significant difference in genotype frequencies between terminal tumor stage (P=0.026) and metastatic groups (P=0.002).

CONCLUSIONS:

The present data indicate that there is a significant association between mutant G of rs11788747 in RECK and WT risk. G carriers with advanced tumor stage or with metastasis might have an increased risk of WT.

• Authors: Yang Yu, Yuanjun Hu, Kaisheng Li, Zhihong Chen, Hongmei Zhang, Lei Zhang
• Journal: Medical science monitor : international medical journal of experimental and clinical research (Med Sci Monit) Vol. 21 Pg. 1928-33 (Jul 03 2015) ISSN: 1643-3750 [Electronic] United States
• PMID: 26141647 (Publication Type: Journal Article)

Chemical References

• GPI-Linked Proteins
• RECK protein, human

Topics

• Case-Control Studies
• Child
• Child, Preschool
• China
• Female
• GPI-Linked Proteins (genetics)
• Genetic Predisposition to Disease
• Humans
• Infant
• Male
• Polymorphism, Single Nucleotide
• Prognosis
• Wilms Tumor (ethnology, genetics, physiopathology)