Abstract | AIM: METHODS: Two soy extracts, M1 and OS, were orally administered to mice with concanavalin A (ConA) immune-mediated hepatitis, to high-fat diet (HFD) mice and to methionine and choline reduced diet combined with HFD mice. Animals were followed for disease and immune biomarkers. RESULTS: CONCLUSION:
Oral administration of the combination of OS and M1 soy derived extracts exerted an adjuvant effect in the gut-immune system, altering the distribution of regulatory T cells, and alleviating immune mediated liver injury, hyperlipidemia and insulin resistance.
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Authors | Tawfik Khoury, Ami Ben Ya'acov, Yehudit Shabat, Lidya Zolotarovya, Ram Snir, Yaron Ilan |
Journal | World journal of gastroenterology
(World J Gastroenterol)
Vol. 21
Issue 24
Pg. 7443-56
(Jun 28 2015)
ISSN: 2219-2840 [Electronic] United States |
PMID | 26139990
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Blood Glucose
- Immunologic Factors
- Insulin
- Lipids
- Plant Extracts
- Tumor Necrosis Factor-alpha
- Concanavalin A
- Methionine
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Topics |
- Administration, Oral
- Animals
- Biomarkers
(blood)
- Blood Glucose
(drug effects, metabolism)
- Chemical and Drug Induced Liver Injury
(blood, immunology, pathology, prevention & control)
- Choline Deficiency
(complications)
- Concanavalin A
- Cytoprotection
- Diet, High-Fat
- Disease Models, Animal
- Immunologic Factors
(administration & dosage)
- Insulin
(blood)
- Insulin Resistance
- Lipids
(blood)
- Liver
(drug effects, immunology, metabolism, pathology)
- Metabolic Syndrome
(immunology, prevention & control)
- Methionine
(deficiency)
- Mice
- Non-alcoholic Fatty Liver Disease
(blood, immunology, pathology, prevention & control)
- Plant Extracts
(administration & dosage)
- Soybeans
- T-Lymphocytes, Regulatory
(drug effects, immunology, metabolism)
- Time Factors
- Tumor Necrosis Factor-alpha
(blood)
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