Abstract | BACKGROUND: AIM: The aim of this study was to determine PTH levels in a large group of healthy children and adolescents. PATIENTS AND METHODS: We retrospectively evaluated PTH levels in 1,580 healthy Caucasian children and adolescents (849 females, 731 males, aged 2.0-17.2 years) with 25-hydroxyvitamin D [25( OH)D] levels ≥ 30 ng/ml. All subjects with genetic, endocrine, hepatic, renal, or other known diseases were excluded. RESULTS: The serum intact PTH concentration (median and inter-quartile range) was 23.00 (15.00-31.60) pg/ml. In our population, the mean 25( OH)D value was 34.27 ± 4.12 ng/ml. The median PTH concentration in boys was 23.00 (15.00-32.00) pg/ml, whereas in girls it was 23.10 (15.00-31.10) pg/ml. However, in girls, PTH levels significantly increased in the age group of 8.1-10.0 years compared to the age group of 2.1-4.0 years (p < 0.0001), whereas in boys it significantly increased in the age groups of 10.1-12.0 years (p < 0.0001) and 12.1-14.0 years (p < 0.0001), leading to the hypothesis of a relationship between PTH level and pubertal and bone growth spurts. CONCLUSIONS: PTH levels in healthy children and adolescents covered a narrower range than the adult values. Obtaining reference values of PTH in childhood and adolescence could aid in the estimation of appropriate values of bone metabolites.
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Authors | Stefano Stagi, Loredana Cavalli, Silvia Ricci, Marina Mola, Cinzia Marchi, Salvatore Seminara, Maria Luisa Brandi, Maurizio de Martino |
Journal | Hormone research in paediatrics
(Horm Res Paediatr)
Vol. 84
Issue 2
Pg. 124-9
( 2015)
ISSN: 1663-2826 [Electronic] Switzerland |
PMID | 26138091
(Publication Type: Journal Article)
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Copyright | © 2015 S. Karger AG, Basel. |
Chemical References |
- Hydroxycholecalciferols
- Parathyroid Hormone
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Topics |
- Adolescent
- Aging
(metabolism)
- Bone Development
(physiology)
- Child
- Child, Preschool
- Female
- Humans
- Hydroxycholecalciferols
(blood)
- Infant
- Italy
- Male
- Parathyroid Hormone
(blood, physiology)
- Puberty
(physiology)
- Reference Values
- Retrospective Studies
- Sex Characteristics
- White People
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