Abstract | OBJECTIVES: METHODS: Using several search terms, we reviewed English language articles on malignant hypertension-induced TMA, indexed in MEDLINE by 31 December 2013. We also report a new case. All these cases were analyzed using descriptive statistics. RESULTS: A total of 19 patients, with 10 males, had a median age of 38 years at diagnosis; 58% had a history of hypertension. Mean arterial pressure at presentation was 159 mmHg (range 123-190 mmHg). All had prominent renal dysfunction (mean creatinine of 5.2 mg/dl, range 1.7-13 mg/dl) but relatively modest thrombocytopenia (mean platelet count of 60 × 103/µl, range 12-131 × 10(3)/µl). Reported cases (n = 9) mostly had preserved ADAMTS-13 activity (mean 64%, range 18-96%). Following blood pressure control, the majority had improvement in presenting symptoms (100%) and platelet counts (84%); however, only 58% had significant improvement in creatinine. More than half (53%) needed hemodialysis. One patient died of cardiac arrest during pacemaker insertion. CONCLUSION:
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Authors | Nabin Khanal, Sumit Dahal, Smrity Upadhyay, Vijaya Raj Bhatt, Philip J Bierman |
Journal | Therapeutic advances in hematology
(Ther Adv Hematol)
Vol. 6
Issue 3
Pg. 97-102
(Jun 2015)
ISSN: 2040-6207 [Print] England |
PMID | 26137201
(Publication Type: Journal Article)
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