Cytolytic activities of benfluron metabolites and loss of transplantability.

Abstract	The cytolytic activity of two benfluron metabolites, namely 7-dihydrobenfluron (DBF) and benfluron N-oxide (NOBF), has been studied using both Ehrlich ascites carcinoma (EAC) and P388 leukaemia cells. DBF showed a considerable cytolytic activity (activity of lactate and malate dehydrogenases, release of protein from the cells into the culture medium, morphological changes) particularly at higher concentrations. The highest concentrations caused a significant prolongation of the survival time of the experimental animals.
Authors	M Miko, J Krepelka, M Melka
Journal	International journal of tissue reactions (Int J Tissue React) Vol. 11 Issue 3 Pg. 143-51 ( 1989) ISSN: 0250-0868 [Print] Switzerland
PMID	2613458 (Publication Type: Journal Article)
Chemical References	Antineoplastic Agents Fluorenes 7-dihydrobenfluron benfluron N-oxide L-Lactate Dehydrogenase Malate Dehydrogenase
Topics	Animals Antineoplastic Agents Carcinoma, Ehrlich Tumor (drug therapy) Cell Membrane (drug effects) Drug Screening Assays, Antitumor Fluorenes (pharmacology) L-Lactate Dehydrogenase (metabolism) Leukemia P388 (drug therapy) Malate Dehydrogenase (metabolism) Mice Spectrophotometry Time Factors Tumor Cells, Cultured

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