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The effect of human leukocyte antigen G alleles on human papillomavirus infection and persistence in a cohort of HIV-positive pregnant women from Brazil.

Abstract
Patients with compromised immune systems have more severe intraepithelial lesions and more rapid disease progression, in addition to increased risk for cervical cancer. Persistent infection by the human papillomavirus (HPV) is a necessary step in that process. By inducing expression of inhibitory ligands of natural killer cells, like HLA-G, HPV avoids the elimination of infected cells. Recent studies have investigated polymorphisms in HLA-G that may be associated with susceptibility to HPV infection and persistence. One hundred-forty HIV(+) pregnant women from Brazil had a DNA fragment comprising HLA-G exons 2-4 PCR-amplified, cloned, sequenced and analyzed for allele determination. Altogether, 22 alleles comprising 52 different genotypes were found. Four novel HLA-G alleles were characterized. We have not observed association of specific HLA-G alleles with HPV infection, but found a protective effect of the G:01:01:02 allele against the occurrence of intraepithelial lesions. In addition to describing new HLA-G alleles and defining new reference sequences, our data provide a better understanding of the impact of HLA-G alleles on HPV-related disease.
AuthorsBrunna M Alves, Isabel M Prellwitz, Juliana D Siqueira, Ângela R Meyrelles, Anke Bergmann, Héctor N Seuánez, Elizabeth S Machado, Marcelo A Soares, Esmeralda A Soares
JournalInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases (Infect Genet Evol) Vol. 34 Pg. 339-43 (Aug 2015) ISSN: 1567-7257 [Electronic] Netherlands
PMID26134300 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2015 Elsevier B.V. All rights reserved.
Chemical References
  • HLA-G Antigens
Topics
  • Brazil
  • Cohort Studies
  • Coinfection (genetics, virology)
  • Female
  • Gene Frequency
  • Genetic Association Studies
  • HIV Infections (genetics, virology)
  • HLA-G Antigens (genetics)
  • Haplotypes
  • Humans
  • Papillomavirus Infections (genetics, virology)
  • Precancerous Conditions (genetics, virology)
  • Pregnancy
  • Uterine Cervical Neoplasms (genetics, virology)

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