Prophylactic Radiotherapy to Intervention Sites in Malignant Pleural Mesothelioma--Single-institution Experience and Literature Review.

Abstract

AIM:

To evaluate the efficacy of prophylactic radiotherapy at intervention sites in patients with malignant pleural mesothelioma (MPM).

PATIENTS AND METHODS:

From 05/2010 to 12/2014, 53 patients with histologically confirmed MPM were treated in order to prevent interventional site metastases. Irradiation was carried out with 3 × 7=21 Gy with 6-18 MeV electrons.

RESULTS:

The mean follow-up period was 14.4 months (range=0-37 months). At the time of the analysis, 20 patients were alive. Three patients had developed a local recurrence within the irradiated site, representing a local recurrence rate of 5.7%. Toxicity was low, with transient grade I erythema found in 20.7% of patients. No grade II or higher toxicity was observed.

CONCLUSION:

Our simple and time-saving RT approach to interventional sites in patients with MPM was both effective and well-tolerated. This approach is easily integrated into general treatment concepts. Until publication of results from prospective randomized trials, prophylactic RT to intervention sites should remain standard.

• Authors: Stefan Janssen, Bernd Schönhofer, Dirk Rades
• Journal: Anticancer research (Anticancer Res) Vol. 35 Issue 7 Pg. 4151-4 (Jul 2015) ISSN: 1791-7530 [Electronic] Greece
• PMID: 26124370 (Publication Type: Journal Article)
• Copyright: Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.

Topics

• Aged
• Aged, 80 and over
• Female
• Humans
• Lung Neoplasms (pathology, radiotherapy)
• Male
• Mesothelioma (pathology, radiotherapy)
• Mesothelioma, Malignant
• Middle Aged
• Neoplasm Recurrence, Local (radiotherapy)
• Pleural Neoplasms (pathology, radiotherapy)