Abstract | OBJECTIVE: To describe the history, refinements, implementation, physiology, and clinical outcomes achieved over the past several centuries of thyroid hormone replacement strategies. METHODS: A Medline search was initiated using the following search terms: bioidentical thyroid hormone, thyroid hormone extract, combination thyroxine (T4) and tri-iodothyronine (T3) therapy, homeopathic thyroid hormone therapy, and thyroid hormone replacement. Pertinent articles of interest were identified by title (and where available abstract) for further review. Additional references were identified during a review of the identified literature. RESULTS: A rich history of physician intervention in thyroid dysfunction was identified dating back more than 2 millennia. Although not precisely documented, thyroid ingestion from animal sources had been used for centuries but was finally scientifically described and documented in Europe over 130 years ago. Since the reports by Bettencourt and Murray, there has been a continuous documentation of outcomes, refinement of hormone preparation production, and updating of recommendations for the most effective and safe use of these hormones for relieving the symptoms of hypothyroidism. As the thyroid extract preparations contain both levothyroxine (LT4) and liothyronine (LT3), current guidelines do not endorse their use as controlled studies do not clearly document enhanced objective outcomes compared with LT4 monotherapy. Among current issues cited, the optimum ratio of LT4 to LT3 has yet to be determined, and the U.S. Food and Drug Administration (FDA) does not appear to be monitoring the thyroid hormone ratios or content in extract preparations on the market. Taken together, these limitations are important detriments to the use of thyroid extract products. CONCLUSION:
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Authors | James V Hennessey |
Journal | Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
(Endocr Pract)
Vol. 21
Issue 10
Pg. 1161-70
(Oct 2015)
ISSN: 1530-891X [Print] United States |
PMID | 26121440
(Publication Type: Historical Article, Journal Article, Review)
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Chemical References |
- Thyroid Hormones
- Tissue Extracts
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Topics |
- Dietary Supplements
- History, 19th Century
- History, 20th Century
- History, 21st Century
- History, Ancient
- Hormone Replacement Therapy
(history, methods)
- Humans
- Hypothyroidism
(therapy)
- Practice Guidelines as Topic
- Thyroid Gland
(chemistry, physiology)
- Thyroid Hormones
(physiology, therapeutic use)
- Tissue Extracts
(pharmacokinetics, therapeutic use)
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