Abstract | OBJECTIVE: MATERIAL AND METHODS: RESULTS: There was a significant increase (p=0.0002) in body mass (in average by 1.5 kg) in 88% patients. A significant increase in the concentration of serum triglycerides was identified as well. The concentration of VLDL in the patients with schizophrenia was 2 times higher compared to controls. After treatment, VLDL concentration increased even more considerably An increase in atherogenic index (AI) was up to 3.1 in patients with schizophrenia compared to 2.2 in controls. After treatment, Al increased up to 4 that demonstrated the high risk of development of atherosclerosis. A significant increase in QT interval in the ECG and heart rate (p=0.03) was revealed only in patients receiving rispolept. In patients receiving zyprexa and seroquel only heart rate was increased. CONCLUSION: The antipsychotics studied increase the risk of development of cardiovascular pathology.
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Authors | L P Smirnova, D A Parshukova, Yu N Borodyuk, E G Kornetova, G D Tkacheva, A A Seregin, T G Burdovitsina, A V Semke |
Journal | Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova
(Zh Nevrol Psikhiatr Im S S Korsakova)
Vol. 115
Issue 3
Pg. 49-53
( 2015)
ISSN: 1997-7298 [Print] Russia (Federation) |
PMID | 26120982
(Publication Type: Journal Article)
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Chemical References |
- Antipsychotic Agents
- Dibenzothiazepines
- Lipoproteins, VLDL
- Benzodiazepines
- Quetiapine Fumarate
- Risperidone
- Olanzapine
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Topics |
- Adult
- Antipsychotic Agents
(adverse effects, therapeutic use)
- Atherosclerosis
(blood, chemically induced)
- Benzodiazepines
(adverse effects, therapeutic use)
- Dibenzothiazepines
(adverse effects, therapeutic use)
- Electrocardiography
- Female
- Humans
- Lipid Metabolism
(drug effects)
- Lipoproteins, VLDL
(blood)
- Male
- Middle Aged
- Olanzapine
- Quetiapine Fumarate
- Risperidone
(adverse effects, therapeutic use)
- Schizophrenia, Paranoid
(blood, drug therapy, physiopathology)
- Weight Gain
- Young Adult
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