Successful treatment of adult-onset collapsing focal segmental glomerulosclerosis with rituximab.

Abstract

Collapsing focal segmental glomerulosclerosis (FSGS), or collapsing glomerulopathy (CG), responds poorly to commonly employed therapies, with a high proportion of patients progressing to end-stage renal disease. We report an adult in a nephrotic state, diagnosed with minimal-change disease on biopsy, who failed to respond to steroids, calcineurin inhibitors (CNIs), mycophenolate mofetil and cyclophosphamide. Repeat biopsy showed CG. Treatment with 4 weekly doses of rituximab led to sustained remission of his nephrotic state. This is the first report of adult-onset CG that has responded favourably to rituximab. Rituximab could be a treatment option for patients with this difficult-to-treat condition.

• Authors: Raja Ramachandran, Venkatesh Rajakumar, Ritambhra Duseja, Vinay Sakhuja, Vivekanand Jha
• Journal: Clinical kidney journal (Clin Kidney J) Vol. 6 Issue 5 Pg. 500-2 (Oct 2013) ISSN: 2048-8505 [Print] England
• PMID: 26120443 (Publication Type: Journal Article)