Abstract |
Nephrotic syndrome is a renal disease accompanied by abnormal body fluid balance. The present experiments investigated the role of behavioral mechanisms in contributing to disordered fluid homeostasis in rats with experimentally-induced nephrotic syndrome. The studies examined water and sodium ingestion under ad libitum conditions and in response to dehydration-related challenges in rats made nephrotic by treatment with the antibiotic, adriamycin. Rats with nephrotic syndrome had greater ad libitum water intakes beginning 3 weeks after treatment, but daily sodium (0.3M NaCl) intakes were not affected. Nephrotic rats showed attenuated water and sodium intakes after combined treatment with furosemide (10mg/kg) and captopril (2mg/kg), reduced water intakes after 20h of water deprivation, and diminished water intakes, plasma renin activity and aldosterone secretion after subcutaneous isoproterenol (30 μg/kg). However, the adriamycin-treated animals had normal water intakes in response to subcutaneous hypertonic saline (4% at 0.75 ml/100g) and central injections of angiotensin II (10, 20, and 50 ng). The results suggest that water and sodium ingestion in response to hypovolemic/hypotensive stimuli are disturbed in nephrotic rats, and provide evidence that the disordered behaviors reflect disturbances of the peripheral renin-angiotensin-aldosterone system.
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Authors | Jie Xu, Alan Kim Johnson, Robert L Thunhorst |
Journal | Physiology & behavior
(Physiol Behav)
Vol. 149
Pg. 317-23
(Oct 01 2015)
ISSN: 1873-507X [Electronic] United States |
PMID | 26120029
(Publication Type: Journal Article, Research Support, N.I.H., Extramural)
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Copyright | Copyright © 2015 Elsevier Inc. All rights reserved. |
Chemical References |
- Antibiotics, Antineoplastic
- Bronchodilator Agents
- Diuretics
- Vasoconstrictor Agents
- Angiotensin II
- Furosemide
- Doxorubicin
- Captopril
- Sodium
- Renin
- Isoproterenol
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Topics |
- Angiotensin II
(pharmacology)
- Animals
- Antibiotics, Antineoplastic
(pharmacology)
- Appetite
(drug effects, physiology)
- Blood Pressure
(drug effects)
- Bronchodilator Agents
(pharmacology)
- Captopril
(pharmacology)
- Disease Models, Animal
- Diuretics
(pharmacology)
- Doxorubicin
(toxicity)
- Drinking
(drug effects)
- Furosemide
(pharmacology)
- Isoproterenol
(pharmacology)
- Male
- Nephrotic Syndrome
(physiopathology)
- Rats
- Rats, Sprague-Dawley
- Renin
(blood)
- Sodium
(metabolism)
- Thirst
(physiology)
- Vasoconstrictor Agents
(pharmacology)
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