Abstract | BACKGROUND & OBJECTIVES: METHODS: OA was induced in right knee of rat by intra-articular injection of 3 mg of MIA and characterized by pathological progression of disease and pain of affected joint. Spontaneous movements, mechanical, thermal and cold sensitivity were monitored at days 0 (before drug and MIA injection), 7, 14 and 21 of MIA administration. EPE (30, 100 and 300 mg/kg), vehicle or etoricoxib (10 mg/ kg; reference drug) were administered daily for 21 days by oral route. RESULTS: EPE at various doses significantly reduced mechanical, heat, cold hyperalgesia and increased the horizontal and vertical movements in intra-articular MIA injected rats. EPE prevented the damage to cartilage structure and reduced the cellular abnormalities. Articular cartilage of rats treated with EPE at 300 mg/kg group was almost normal with well-developed smooth surface and chondrocytes were distributed individually or arranged in column. INTERPRETATION & CONCLUSIONS: The present findings showed that the EPE was not only able to mitigate pain and hyperalgesia but also inhibited MIA-induced cartilage degeneration in vivo. EPE may have the potential to become therapeutic modality in the treatment of osteoarthritis. However, further studies need to be done to confirm these findings in other models and clinical trials.
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Authors | Rashmi R Kumari, Amar S More, Gaurav Gupta, Madhu C Lingaraju, Venkanna Balaganur, Pankaj Kumar, Dinesh Kumar, Anil K Sharma, Santosh K Mishra, Surendra Kumar Tandan |
Journal | The Indian journal of medical research
(Indian J Med Res)
Vol. 141
Issue 4
Pg. 454-62
(Apr 2015)
ISSN: 0971-5916 [Print] India |
PMID | 26112847
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Iodoacetates
- Plant Extracts
|
Topics |
- Animals
- Arthritis, Experimental
(chemically induced, drug therapy, pathology)
- Cartilage, Articular
(drug effects)
- Chondrocytes
(drug effects)
- Disease Models, Animal
- Fabaceae
(chemistry)
- Humans
- Injections, Intra-Articular
- Iodoacetates
(toxicity)
- Male
- Osteoarthritis
(chemically induced, drug therapy, pathology)
- Pain
(drug therapy, pathology)
- Plant Extracts
(administration & dosage, chemistry)
- Rats
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