ESEM Detection of Foreign Metallic Particles inside Ameloblastomatous Cells.

Abstract

Ameloblastoma is a borderline tumor of odontogenic origin, with a high recurrence rate and possible local aggressiveness. The etiopathogenetic factors involved in its occurrence are not still defined and our study has been precisely aimed to search for novel factors associated with its development. Sections cut from paraffin blocks, containing the representative specimens of 18 different ameloblastomas, collected in a 15-year period (1999-2014), have been observed by an environmental scanning electron microscope, in order to search micro- and nano-sized particles and to identify their composition. In all the neoplastic cases, micro- and nano-sized metallic debris, differing in size and composition, have been detected inside the ameloblastomatous cells. On the contrary, the total absence of metallic particles in the healthy control cases has been emerged. Our results reveal a relationship between ameloblastoma and metallic particulate. The cigarette smoke and the routine dental practice appear the most probable source for the presence of these biopersistant inorganic particles inside the neoplastic cells.

• Authors: Luca Roncati, Antonietta Morena Gatti, Teresa Pusiol, Giuseppe Barbolini, Antonio Maiorana, Stefano Montanari
• Journal: Ultrastructural pathology (Ultrastruct Pathol) Vol. 39 Issue 5 Pg. 329-35 ( 2015) ISSN: 1521-0758 [Electronic] England
• PMID: 26111111 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Metals

Topics

• Adult
• Aged
• Aged, 80 and over
• Ameloblastoma (chemistry, ultrastructure)
• Female
• Foreign Bodies
• Humans
• Jaw Neoplasms (chemistry, ultrastructure)
• Male
• Metals (analysis)
• Microscopy, Electron, Scanning (methods)
• Middle Aged
• Young Adult