Developments in impulse control behaviours of Parkinson's disease.

Abstract

PURPOSE OF REVIEW:

Impulse control behaviours (ICBs) are a frequent comorbidity for patients with Parkinson's disease. They consist of impulse control disorders, dopamine dysregulation syndrome, and punding. The field continues to evolve in the understanding of impulsivity and assessment of risk factors in the development of these behaviours and their appropriate management in patients with Parkinson's disease.

RECENT FINDINGS:

Impulsivity is a multifaceted concept that is surprisingly common in untreated patients with Parkinson's disease. The incidence of ICBs increases with demographic, clinical, and biochemical risk factors. Treatments rely on reduction of dopamine agonists with exception of cognitive behavioural therapy and possibly repetitive transcranial magnetic stimulation.

SUMMARY:

Reduction of dopamine agonist dose is the mainstay of treatment of ICBs. Other forms of dopaminergic treatment such as deep brain stimulation or jejunal infusion are alternative treatments but may be complicated by dopamine agonist withdrawal syndrome. Other therapies show promise but data are insufficient to suggest their regular use.

• Authors: Mateusz Zurowski, Jonathan Darcy O'Brien
• Journal: Current opinion in neurology (Curr Opin Neurol) Vol. 28 Issue 4 Pg. 387-92 (Aug 2015) ISSN: 1473-6551 [Electronic] England
• PMID: 26110803 (Publication Type: Journal Article, Review)

Chemical References

• Dopamine Agonists

Topics

• Deep Brain Stimulation
• Disruptive, Impulse Control, and Conduct Disorders (complications, drug therapy, psychology)
• Dopamine Agonists (therapeutic use)
• Humans
• Impulsive Behavior (physiology)
• Parkinson Disease (complications, drug therapy, psychology)