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Bortezomib-induced acute interstitial nephritis.

Abstract
Acute interstitial nephritis (AIN) is one of the important causes of acute kidney injury (AKI) resulting from inflammatory tubulointerstitial injury induced by medications, infections and systemic diseases. Bortezomib has been increasingly used especially in renal related indications such as multiple myeloma and monoclonal gammopathy of renal significance. Severe allergic reactions from bortezomib treatment including AIN have not been described in the literature. We report a 47-year-old white man who developed biopsy-proven allergic AIN after treatment with bortezomib for his C3 glomerulonephritis. The patient's kidney function improved after treatment with glucocorticoid therapy and discontinuation of bortezomib, but worsened with recurrent AKI episode after re-initiation of bortezomib. His renal function improved after glucocorticoid therapy and discontinuation of bortezomib. To our knowledge, this is the first report of a biopsy-proven AIN from bortezomib.
AuthorsWisit Cheungpasitporn, Nelson Leung, S Vincent Rajkumar, Lynn D Cornell, Sanjeev Sethi, Andrea Angioi, Fernando C Fervenza
JournalNephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (Nephrol Dial Transplant) Vol. 30 Issue 7 Pg. 1225-9 (Jul 2015) ISSN: 1460-2385 [Electronic] England
PMID26109684 (Publication Type: Case Reports, Journal Article)
Copyright© The Author 2015. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.
Chemical References
  • Antineoplastic Agents
  • Bortezomib
Topics
  • Antineoplastic Agents (adverse effects)
  • Bortezomib (adverse effects)
  • Glomerulonephritis (complications, drug therapy)
  • Humans
  • Male
  • Middle Aged
  • Nephritis, Interstitial (chemically induced, prevention & control)
  • Prognosis

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