The Level of Squamous Cell Carcinoma Antigen and Lymph Node Metastasis in Locally Advanced Cervical Cancer.

Abstract

BACKGROUND:

This study aimed to determine the utility and a cut-off level of serum squamous cell carcinoma antigen (SCC-Ag) to predict lymph node metastasis in locally advanced cervical cancer cases. We also investigated the correlation between SCC-Ag level and lymph node status.

MATERIALS AND METHODS:

From June 2009 to June 2014, 232 patients with cervical cancer stage IB2-IVA, who were treated at Ramathibodi Hospital, were recruited. Receiver operating characteristic (ROC) curves were used to identify the best cut-off point of SCC-Ag level to predict lymph node metastasis. Quantile regression was performed to evaluate the correlation between SCC-Ag levels and pelvic lymph node metastasis, paraaortic lymph node metastasis, and parametrial involvement as well as tumor size.

RESULTS:

Pelvic lymph node metastasis and paraaortic lymph node metastasis were diagnosed in 46.6% and 20.1% of the patients, respectively. The median SCC-Ag level was 6 ng/mL (range, 0.5 to 464.6 ng/ mL). The areas under ROC curves between SCC-Ag level and pelvic lymph node metastasis, paraaotic lymph node metastasis, parametrial involvements were low. SCC-Ag level was significantly correlated with paraaortic lymph node status (p=0.045) but not with pelvic lymph node status and parametrial involvement. SCC-Ag level was also related to the tumor diameter (p<0.05).

CONCLUSIONS:

SCC-Ag level is not a good predictor for pelvic and paraaortic lymph node metastasis. However, it is still beneficial to assess the tumor burden of squamous cell carcinoma of the cervix.

• Authors: Navamol Lekskul, Chuenkamon Charakorn, Arb-Aroon Lertkhachonsuk, Sasivimol Rattanasiri, Nathpong Israngura Na Ayudhya
• Journal: Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 16 Issue 11 Pg. 4719-22 ( 2015) ISSN: 2476-762X [Electronic] Thailand
• PMID: 26107230 (Publication Type: Journal Article)

Chemical References

• Antigens, Neoplasm
• Serpins
• squamous cell carcinoma-related antigen

Topics

• Antigens, Neoplasm (metabolism)
• Carcinoma, Adenosquamous (metabolism, secondary)
• Carcinoma, Squamous Cell (metabolism, secondary)
• Female
• Follow-Up Studies
• Humans
• Immunoassay
• Lymphatic Metastasis
• Neoplasm Staging
• Para-Aortic Bodies (metabolism, pathology)
• Pelvic Neoplasms (metabolism, secondary)
• Prognosis
• Serpins (metabolism)
• Uterine Cervical Neoplasms (metabolism, pathology)