Mechanism of La Crosse virus inhibition by ribavirin.

Abstract	The effect of ribavirin on the growth and replication of La Crosse virus was examined. The data suggest that low concentrations of ribavirin have a marked effect on the initial steps of La Crosse virus transcription. The therapeutic potential of ribavirin in the treatment of human California encephalitis serotype infections is discussed in light of these findings.
Authors	L F Cassidy, J L Patterson
Journal	Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 33 Issue 11 Pg. 2009-11 (Nov 1989) ISSN: 0066-4804 [Print] United States
PMID	2610511 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)
Chemical References	Chlorides Nucleic Acid Synthesis Inhibitors Ribonucleosides Cesium Ribavirin cesium chloride
Topics	Bunyaviridae (drug effects) Cesium (pharmacology) Chlorides Encephalitis Virus, California (drug effects, physiology) Encephalitis, California (drug therapy) Nucleic Acid Synthesis Inhibitors Peptide Chain Elongation, Translational (drug effects) Ribavirin (pharmacology, therapeutic use) Ribonucleosides (pharmacology) Transcription, Genetic (drug effects) Virus Replication (drug effects)

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