Abstract | OBJECTIVES: Our study investigates the effects of nitric oxide (NO) deficiency during pregnancy on coagulation and fibrinolysis balance in fetal circulation. MAIN OUTCOME MEASURES: RESULTS:
L-NAME treatment in pregnant rats caused significant SBP elevation and severe proteinuria. In the L-NAME-treated group, weights of fetuses and placentae were diminished. tPA mRNA expression decreased in the umbilical cord and placenta, whereas TF and TFPI mRNA levels did not change. Intense PAI-1 immunoreactivity was observed in a part of degenerated placenta. In the aorta, tPA mRNA expression increased in the L-NAME-treated group, while TFPI mRNA levels were lower than in controls. CONCLUSIONS: NO deficiency during pregnancy decreased tPA mRNA expression in the umbilical cord and placenta but not in the maternal aorta. Imbalance between coagulation and fibrinolysis in fetal and maternal circulations may, at least in part, contribute to fetal growth restriction.
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Authors | Yuuka Mukai, Shin Sato |
Journal | Pregnancy hypertension
(Pregnancy Hypertens)
Vol. 2
Issue 1
Pg. 53-8
(Jan 2012)
ISSN: 2210-7789 [Print] Netherlands |
PMID | 26104991
(Publication Type: Journal Article)
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Copyright | Copyright © 2011 International Society for the Study of Hypertension in Pregnancy. Published by Elsevier B.V. All rights reserved. |