Abstract | AIM:
Electrolyte balances have not been sufficiently evaluated in extremely preterm infants after early parenteral nutrition. We investigated the risk of early hypophosphatemia and hypokalemia in extremely preterm infants born small for gestational age (SGA) who received nutrition as currently recommended. METHODS: This prospective, observational cohort study included all consecutive extremely preterm infants born at 24-27 weeks who received high amino acids and lipid perfusion from birth. We evaluated the electrolyte levels of SGA infants and infants born appropriate for gestational age (AGA) during the first five days of life. RESULTS: The 12 SGA infants had lower plasma potassium levels from Day One compared to the 36 AGA infants and were more likely to have hypokalemia (58% vs 17%, p = 0.001) and hypophosphatemia (40% vs 9%, p < 0.01) during the five-day observation period. After adjusting for perinatal factors, SGA remained significantly associated with hypophosphatemia (odds ratio 1.39, confidence intervals 1.07-1.81, p = 0.01). CONCLUSION:
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Authors | F Boubred, E Herlenius, M Bartocci, B Jonsson, M Vanpée |
Journal | Acta paediatrica (Oslo, Norway : 1992)
(Acta Paediatr)
Vol. 104
Issue 11
Pg. 1077-83
(Nov 2015)
ISSN: 1651-2227 [Electronic] Norway |
PMID | 26100071
(Publication Type: Journal Article, Observational Study, Research Support, Non-U.S. Gov't)
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Copyright | ©2015 Foundation Acta Paediatrica. Published by John Wiley & Sons Ltd. |
Topics |
- Age Factors
- Cohort Studies
- Female
- Humans
- Hypokalemia
(epidemiology, etiology)
- Hypophosphatemia
(epidemiology, etiology)
- Infant, Extremely Premature
- Infant, Newborn
- Infant, Small for Gestational Age
- Male
- Parenteral Nutrition
(adverse effects)
- Prospective Studies
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