[Ocular hypertension after intravitreal steroid injections: Clinical update as of 2015].

Abstract

Intravitreal injections are a therapeutic delivery method best suited to the treatment of retinal diseases. Recent years have been marked by the use of anti-VEGF agents as well as the arrival of sustained-release corticosteroid implants in France, replacing triamcinolone acetonide. A common complication of IVT steroids is secondary ocular hypertension (OHT) resulting from increased outflow resistance. This article summarizes current understanding. OHT induced by topical steroids has been described for 60 years. Intravitreal use also shows a temporary effect if the exposure is short, dose dependence, and varying incidence depending on the drug used. Sustained release formulations and discontinuing treatment have reduced the risk of induced OHT. Risk factors that induce OHT must be clearly identified prior to an injection. Most cases of OHT can be controlled medically, although differences exist between different drugs. In cases where it cannot be controlled, removal of the implant, selective laser trabeculoplasty, and filtration surgery can be discussed.

• Authors: C Dot, H El Chehab, A Russo, E Agard
• Journal: Journal francais d'ophtalmologie (J Fr Ophtalmol) Vol. 38 Issue 7 Pg. 656-64 (Sep 2015) ISSN: 1773-0597 [Electronic] France
• Vernacular Title: Hypertonie oculaire après injections intra-vitréennes de corticoïdes, actualisation des connaissances en 2015.
• PMID: 26099427 (Publication Type: English Abstract, Journal Article, Review)
• Copyright: Copyright © 2015 Elsevier Masson SAS. All rights reserved.

Chemical References

• Adrenal Cortex Hormones
• Delayed-Action Preparations
• Drug Implants
• Ointments
• Ophthalmic Solutions
• Fluocinolone Acetonide
• Dexamethasone
• Triamcinolone Acetonide
• Acetazolamide

Topics

• Acetazolamide (therapeutic use)
• Adrenal Cortex Hormones (administration & dosage, adverse effects)
• Adult
• Animals
• Child
• Delayed-Action Preparations
• Dexamethasone (administration & dosage, adverse effects)
• Dose-Response Relationship, Drug
• Drug Implants
• Filtering Surgery
• Fluocinolone Acetonide (administration & dosage, adverse effects)
• Humans
• Intravitreal Injections
• Ocular Hypertension (chemically induced, drug therapy, prevention & control, surgery)
• Ointments
• Ophthalmic Solutions
• Rabbits
• Retinal Diseases (drug therapy)
• Risk Factors
• Triamcinolone Acetonide (administration & dosage, adverse effects)