Abstract | INTRODUCTION: AREAS COVERED: This article summarizes the pharmacokinetics, pharmacodynamics, mechanisms of action, safety, tolerability, pre-clinical studies and clinical trials of the HDAC inhibitor entinostat, as a novel promissory agent for the treatment of NSCLC. EXPERT OPINION: The field of targeted therapy has increased in lung cancer. However, even now with the current FDA-approved agents, < 15% of patients benefit from these interventions and we are still far from curing lung cancer. New targets are needed. Either in combination with cytotoxic drugs, epigenetic therapy or other molecular targeted drugs, entinostat represents a new potential agent for the treatment of non- small cell carcinomas. However, the preliminary safety and efficacy results from several clinical trials still need to be validated in large Phase III trials.
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Authors | Rossana Ruiz, Luis E Raez, Christian Rolfo |
Journal | Expert opinion on investigational drugs
(Expert Opin Investig Drugs)
Vol. 24
Issue 8
Pg. 1101-9
( 2015)
ISSN: 1744-7658 [Electronic] England |
PMID | 26098363
(Publication Type: Journal Article, Review)
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Chemical References |
- Antineoplastic Agents
- Benzamides
- Histone Deacetylase Inhibitors
- Pyridines
- entinostat
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Topics |
- Animals
- Antineoplastic Agents
(adverse effects, pharmacology, therapeutic use)
- Benzamides
(adverse effects, pharmacology, therapeutic use)
- Carcinoma, Non-Small-Cell Lung
(drug therapy, genetics, pathology)
- Epigenesis, Genetic
- Histone Deacetylase Inhibitors
(adverse effects, pharmacology, therapeutic use)
- Humans
- Lung Neoplasms
(drug therapy, genetics, pathology)
- Molecular Targeted Therapy
- Pyridines
(adverse effects, pharmacology, therapeutic use)
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