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Effect of 0.3% Hydroxypropyl Methylcellulose/Dextran Versus 0.18% Sodium Hyaluronate in the Treatment of Ocular Surface Disease in Glaucoma Patients: A Randomized, Double-Blind, and Controlled Study.

AbstractPURPOSE:
To compare the efficacy and safety of 0.3% hydroxypropyl methylcellulose/dextran (HPMC/dextran) and 0.18% sodium hyaluronate (SH) in the treatment of ocular surface disease in patients using antiglaucoma drugs containing preservatives.
METHODS:
This was a double-blind, randomized, parallel-group study in 70 glaucoma patients with Ocular Surface Disease Index (OSDI) score greater than 20 points and/or presence of ocular signs. Patients were randomized to receive either preservative-free 0.3% HPMC/dextran (n=35) or preservative-free 0.18% SH (n=35). Treatment was 1 drop in each eye, 4 times a day. Data were collected at baseline, at day 7 and day 28.
RESULTS:
The groups were homogeneous at baseline. At day 28, both treatments showed significant improvements (P<0.05) in the mean OSDI score, lid skin and lid margin inflammation, conjunctival injection, and expressibility of meibomian glands, corneal staining score, fluorescein tear breakup time (FBUT), and Schirmer I test. However, the mean OSDI score, lid margin inflammation and conjunctival injection showed significant improvements (P<0.05) in the SH group at days 7 and 28, compared to the HPMC/dextran group. FBUT and the Schirmer I test also showed significant improvements (P<0.05) in the SH group compared to the HPMC/dextran group, at day 28. No adverse reactions were observed in either group.
CONCLUSIONS:
Preservative-free artificial tear, 0.3% HPMC/dextran, and 0.18% SH, caused a significant relief of the ocular surface disease in glaucoma patients. However, 0.18% SH led to a greater improvement in ocular signs and symptoms than 0.3% HPMC/dextran.
AuthorsPinnita Prabhasawat, Ngamkae Ruangvaravate, Nattaporn Tesavibul, Maneerat Thewthong
JournalJournal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics (J Ocul Pharmacol Ther) 2015 Jul-Aug Vol. 31 Issue 6 Pg. 323-9 ISSN: 1557-7732 [Electronic] United States
PMID26090941 (Publication Type: Journal Article, Randomized Controlled Trial)
Chemical References
  • Dextrans
  • Lubricant Eye Drops
  • Preservatives, Pharmaceutical
  • Hypromellose Derivatives
  • Hyaluronic Acid
Topics
  • Administration, Topical
  • Dextrans (administration & dosage, adverse effects)
  • Double-Blind Method
  • Female
  • Glaucoma (drug therapy, physiopathology)
  • Humans
  • Hyaluronic Acid (administration & dosage, adverse effects)
  • Hypromellose Derivatives (administration & dosage, adverse effects)
  • Lubricant Eye Drops (administration & dosage)
  • Male
  • Meibomian Glands (drug effects, physiopathology)
  • Preservatives, Pharmaceutical (administration & dosage)
  • Prospective Studies
  • Treatment Outcome

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