Abstract | PURPOSE: METHODS: This was a double-blind, randomized, parallel-group study in 70 glaucoma patients with Ocular Surface Disease Index (OSDI) score greater than 20 points and/or presence of ocular signs. Patients were randomized to receive either preservative-free 0.3% HPMC/ dextran (n=35) or preservative-free 0.18% SH (n=35). Treatment was 1 drop in each eye, 4 times a day. Data were collected at baseline, at day 7 and day 28. RESULTS: The groups were homogeneous at baseline. At day 28, both treatments showed significant improvements (P<0.05) in the mean OSDI score, lid skin and lid margin inflammation, conjunctival injection, and expressibility of meibomian glands, corneal staining score, fluorescein tear breakup time (FBUT), and Schirmer I test. However, the mean OSDI score, lid margin inflammation and conjunctival injection showed significant improvements (P<0.05) in the SH group at days 7 and 28, compared to the HPMC/ dextran group. FBUT and the Schirmer I test also showed significant improvements (P<0.05) in the SH group compared to the HPMC/ dextran group, at day 28. No adverse reactions were observed in either group. CONCLUSIONS: Preservative-free artificial tear, 0.3% HPMC/ dextran, and 0.18% SH, caused a significant relief of the ocular surface disease in glaucoma patients. However, 0.18% SH led to a greater improvement in ocular signs and symptoms than 0.3% HPMC/ dextran.
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Authors | Pinnita Prabhasawat, Ngamkae Ruangvaravate, Nattaporn Tesavibul, Maneerat Thewthong |
Journal | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics
(J Ocul Pharmacol Ther)
2015 Jul-Aug
Vol. 31
Issue 6
Pg. 323-9
ISSN: 1557-7732 [Electronic] United States |
PMID | 26090941
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Dextrans
- Lubricant Eye Drops
- Preservatives, Pharmaceutical
- Hypromellose Derivatives
- Hyaluronic Acid
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Topics |
- Administration, Topical
- Dextrans
(administration & dosage, adverse effects)
- Double-Blind Method
- Female
- Glaucoma
(drug therapy, physiopathology)
- Humans
- Hyaluronic Acid
(administration & dosage, adverse effects)
- Hypromellose Derivatives
(administration & dosage, adverse effects)
- Lubricant Eye Drops
(administration & dosage)
- Male
- Meibomian Glands
(drug effects, physiopathology)
- Preservatives, Pharmaceutical
(administration & dosage)
- Prospective Studies
- Treatment Outcome
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