Effect of 0.3% Hydroxypropyl Methylcellulose/Dextran Versus 0.18% Sodium Hyaluronate in the Treatment of Ocular Surface Disease in Glaucoma Patients: A Randomized, Double-Blind, and Controlled Study.

To compare the efficacy and safety of 0.3% hydroxypropyl methylcellulose/dextran (HPMC/dextran) and 0.18% sodium hyaluronate (SH) in the treatment of ocular surface disease in patients using antiglaucoma drugs containing preservatives.
This was a double-blind, randomized, parallel-group study in 70 glaucoma patients with Ocular Surface Disease Index (OSDI) score greater than 20 points and/or presence of ocular signs. Patients were randomized to receive either preservative-free 0.3% HPMC/dextran (n=35) or preservative-free 0.18% SH (n=35). Treatment was 1 drop in each eye, 4 times a day. Data were collected at baseline, at day 7 and day 28.
The groups were homogeneous at baseline. At day 28, both treatments showed significant improvements (P<0.05) in the mean OSDI score, lid skin and lid margin inflammation, conjunctival injection, and expressibility of meibomian glands, corneal staining score, fluorescein tear breakup time (FBUT), and Schirmer I test. However, the mean OSDI score, lid margin inflammation and conjunctival injection showed significant improvements (P<0.05) in the SH group at days 7 and 28, compared to the HPMC/dextran group. FBUT and the Schirmer I test also showed significant improvements (P<0.05) in the SH group compared to the HPMC/dextran group, at day 28. No adverse reactions were observed in either group.
Preservative-free artificial tear, 0.3% HPMC/dextran, and 0.18% SH, caused a significant relief of the ocular surface disease in glaucoma patients. However, 0.18% SH led to a greater improvement in ocular signs and symptoms than 0.3% HPMC/dextran.
AuthorsPinnita Prabhasawat, Ngamkae Ruangvaravate, Nattaporn Tesavibul, Maneerat Thewthong
JournalJournal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics (J Ocul Pharmacol Ther) 2015 Jul-Aug Vol. 31 Issue 6 Pg. 323-9 ISSN: 1557-7732 [Electronic] United States
PMID26090941 (Publication Type: Journal Article, Randomized Controlled Trial)
Chemical References
  • Dextrans
  • Lubricant Eye Drops
  • Preservatives, Pharmaceutical
  • Hypromellose Derivatives
  • Hyaluronic Acid
  • Administration, Topical
  • Dextrans (administration & dosage, adverse effects)
  • Double-Blind Method
  • Female
  • Glaucoma (drug therapy, physiopathology)
  • Humans
  • Hyaluronic Acid (administration & dosage, adverse effects)
  • Hypromellose Derivatives (administration & dosage, adverse effects)
  • Lubricant Eye Drops (administration & dosage)
  • Male
  • Meibomian Glands (drug effects, physiopathology)
  • Preservatives, Pharmaceutical (administration & dosage)
  • Prospective Studies
  • Treatment Outcome

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research graph!

Choose Username:
Verify Password:
Enter Code Shown: