Abstract | OBJECTIVE: METHODS: Twenty-three patients in whom cognitive impairment occurred at least one year after a diagnosis of PD participated in this open-label trial. Cognitive, psychiatric, and motor symptoms were assessed before and after 24 weeks of treatment with rivastigmine using unstructured clinical assessments and rating scales including the Unified Parkinson's Disease Rating Scale, Mini-Mental State Examination (MMSE), and the Neuropsychiatric Inventory. RESULTS: Age (± standard deviation) was 74.7 ± 5.9 years, average duration of PD was 3.5 ± 3.7 years, Hoehn and Yahr scores were 2.2 ± 0.8, and baseline MMSE scores were 19.1 ± 4.2. Improvements in global mental symptoms and neuropsychiatric symptoms were significant; among them, hallucination, depression and appetite changes improved. Caregiver distress significantly decreased, including distress resulting from hallucinations, depression, apathy, and appetite changes. CONCLUSIONS: Although controlled trials are required, the findings suggest that rivastigmine is useful for control of several neuropsychiatric symptoms and beneficial for caregiver distress in patients with PDD.
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Authors | Yoon-Sang Oh, Joong-Seok Kim, Phil Hyu Lee |
Journal | Journal of movement disorders
(J Mov Disord)
Vol. 8
Issue 2
Pg. 98-102
(May 2015)
ISSN: 2005-940X [Print] Korea (South) |
PMID | 26090082
(Publication Type: Journal Article)
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