Comparing three toothpastes in controlling plaque and gingivitis: A 6-month clinical study.

Abstract

PURPOSE:

To investigate the clinical efficacy of three toothpastes in controlling established gingivitis and plaque over 6 months.

METHODS:

135 subjects were enrolled in a single-center, double-blind, parallel group, randomized clinical study. Subjects were randomly assigned to one of three treatments: triclosan/copolymer/fluoride dentifrice containing 0.3% triclosan, 2.0% copolymer and 1,450 ppm F as sodium fluoride in a silica base; herbal/bicarbonate dentifrice containing herbal extract and 1,400 ppm F as sodium fluoride in a sodium bicarbonate base; or fluoride dentifrice containing 450 ppm F as sodium fluoride, and 1,000 ppm F as sodium monofluorophosphate. Subjects were instructed to brush their teeth twice daily for 1 minute for 6 months.

RESULTS:

After 6 months, subjects assigned to the triclosan/copolymer/fluoride group exhibited statistically significant reductions in gingival index scores and plaque index scores as compared to subjects assigned to the herbal/bicarbonate group by 35.4% and 48.9%, respectively. There were no statistically significant differences in gingival index and plaque index between subjects in the herbal/ bicarbonate group and those in the fluoride group. The triclosan/copolymer/fluoride dentifrice was statistically significantly more effective in reducing gingivitis and dental plaque than the herbal/bicarbonate dentifrice, and this difference in efficacy was clinically meaningful.

• Authors: Terdphong Triratana, Petcharat Kraivaphan, Cholticha Amornchat, Luis R Mateo, Boyce M Morrison Jr, Serge Dibart, Yun-Po Zhang
• Journal: American journal of dentistry (Am J Dent) Vol. 28 Issue 2 Pg. 68-74 (Apr 2015) ISSN: 0894-8275 [Print] United States
• PMID: 26087570 (Publication Type: Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)

Chemical References

• Anti-Infective Agents, Local
• Dentifrices
• Phosphates
• Plant Extracts
• Toothpastes
• fluorophosphate
• Triclosan
• Sodium Bicarbonate
• Sodium Fluoride
• Fluorides

Topics

• Adolescent
• Adult
• Aged
• Anti-Infective Agents, Local (therapeutic use)
• Dental Plaque (prevention & control)
• Dental Plaque Index
• Dentifrices (therapeutic use)
• Double-Blind Method
• Female
• Fluorides (therapeutic use)
• Follow-Up Studies
• Gingivitis (prevention & control)
• Humans
• Male
• Middle Aged
• Periodontal Index
• Phosphates (therapeutic use)
• Phytotherapy (methods)
• Plant Extracts (therapeutic use)
• Sodium Bicarbonate (therapeutic use)
• Sodium Fluoride (therapeutic use)
• Toothbrushing (methods)
• Toothpastes (therapeutic use)
• Treatment Outcome
• Triclosan (therapeutic use)
• Young Adult