Genetic association between VEGF polymorphisms and BRONJ in the Korean population.

Abstract

OBJECTIVES:

The purpose of this study was to evaluate the association between vascular endothelial growth factor (VEGF) polymorphisms and bisphosphonate-related osteonecrosis of the jaw (BRONJ) in the Korean population.

SUBJECTS AND METHODS:

Forty-five individuals (2 men, 43 women; mean age: 68.7 ± 12.3 years) were recruited for this study. All visited the Yonsei University Dental Hospital for surgical intervention from January 2012 to January 2013 and had a history of bisphosphonate (BP) administration (oral and/or intravenous). Patients were allocated to case (n = 26) or control (n = 19) groups according to the patients' selection criteria. Association between three VEGF single nucleotide polymorphisms (rs699947 (-2578 C>A), rs2010963 (-634 G>C) and rs3025039 (+936 C>T)) and BRONJ were investigated using multiple logistic regression analysis and Fisher's exact test where appropriate (α = 0.05).

RESULTS:

The CC homozygotes of rs2010963 and rs3025039 of VEGF gene were associated with an increased risk of BRONJ (P = 0.04, 0.03, respectively). In haplotype analysis, no differences in haplotype C-C (-2578/-634) and haplotype C-C-C (-2578/-634/+936) were observed.

CONCLUSION:

The CC homozygotes of rs2010963 and rs3025039 polymorphisms in the VEGF gene were associated with an increased risk of BRONJ in the Korean population. Further epidemiological cohort studies with a larger sample size would be required to confirm the suggestive correlations.

• Authors: H Choi, J H Lee, H J Kim, W Park, J-H Lee, J-H Kim
• Journal: Oral diseases (Oral Dis) Vol. 21 Issue 7 Pg. 866-71 (Oct 2015) ISSN: 1601-0825 [Electronic] Denmark
• PMID: 26086871 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

Chemical References

• Vascular Endothelial Growth Factor A

Topics

• Aged
• Aged, 80 and over
• Asian People (genetics)
• Bisphosphonate-Associated Osteonecrosis of the Jaw (genetics)
• Case-Control Studies
• Female
• Haplotypes
• Homozygote
• Humans
• Male
• Middle Aged
• Polymorphism, Single Nucleotide
• Republic of Korea
• Vascular Endothelial Growth Factor A (genetics)