Abstract | OBJECTIVES: MATERIALS AND METHODS: There were 56 patients with immunoglobulin A nephropathy who had renal transplant between 1989 and 2005. We categorized recipient age into < or ≥ 20 years at transplant. Each age category was divided into 2 levels based on recurrence. RESULTS: The recurrence rate was higher in patients aged < 20 years(53.8%) than ≥ 20 years. Proteinuria was more frequently diagnosed in patients aged < 20 years (57.1% vs 25.0%; P = .047). In patients aged ≥ 20 years, the duration of dialysis was 4.55 months in the recurrence group and 17.78 months in the no recurrence group (P = .032). Time from progressive symptoms to renal replacement therapy was significantly shorter in patients aged ≥ 20 years with recurrence than patients aged ≥ 20 years with no recurrence. The univariate relative risk of recurrent immunoglobulin A nephropathy after transplant was 9.8 for recipients aged ≥ 20 years who had progressive symptoms to renal replacement therapy < 24 months (P = .046). CONCLUSIONS: Patients aged < 20 years had more rapid disease progression to end-stage renal disease and a higher recurrence rate after transplant than patients aged ≥ 20 years. If patients aged ≥ 20 years progress rapidly from progressive symptoms to renal replacement therapy, renal transplant may be considered after 24 months because of high recurrence risk.
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Authors | Sanghyun Ahn, Sang-Il Min, Seung-Kee Min, Il Soo Ha, Hee Gyung Kang, Yon Su Kim, Sang Joon Kim, Jongwon Hao |
Journal | Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation
(Exp Clin Transplant)
Vol. 13
Issue 3
Pg. 227-32
(Jun 2015)
ISSN: 2146-8427 [Electronic] Turkey |
PMID | 26086832
(Publication Type: Comparative Study, Journal Article)
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Topics |
- Adolescent
- Adult
- Age Factors
- Child
- Disease Progression
- Female
- Glomerulonephritis, IGA
(complications, diagnosis, surgery)
- Graft Survival
- Humans
- Kidney Failure, Chronic
(diagnosis, etiology, surgery)
- Kidney Transplantation
(adverse effects)
- Male
- Middle Aged
- Recurrence
- Retrospective Studies
- Risk Factors
- Time Factors
- Treatment Outcome
- Young Adult
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