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Testicular Cancer, Version 2.2015.

Abstract
Germ cell tumors (GCTs) account for 95% of testicular cancers. Testicular GCTs constitute the most common solid tumor in men between the ages of 20 and 34 years, and the incidence of testicular GCTs has been increasing in the past 2 decades. Testicular GCTs are classified into 2 broad groups--pure seminoma and nonseminoma--which are treated differently. Pure seminomas, unlike nonseminomas, are more likely to be localized to the testis at presentation. Nonseminoma is the more clinically aggressive tumor associated with elevated serum concentrations of alphafetoprotein (AFP). The diagnosis of a seminoma is restricted to pure seminoma histology and a normal serum concentration of AFP. When both seminoma and elements of a nonseminoma are present, management follows that for a nonseminoma. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Testicular Cancer outline the diagnosis, workup, risk assessment, treatment, and follow-up schedules for patients with both pure seminoma and nonseminoma.
AuthorsRobert J Motzer, Eric Jonasch, Neeraj Agarwal, Clair Beard, Sam Bhayani, Graeme B Bolger, Sam S Chang, Toni K Choueiri, Brian A Costello, Ithaar H Derweesh, Shilpa Gupta, Steven L Hancock, Jenny J Kim, Timothy M Kuzel, Elaine T Lam, Clayton Lau, Ellis G Levine, Daniel W Lin, M Dror Michaelson, Thomas Olencki, Roberto Pili, Elizabeth R Plimack, Edward N Rampersaud, Bruce G Redman, Charles J Ryan, Joel Sheinfeld, Brian Shuch, Kanishka Sircar, Brad Somer, Richard B Wilder, Mary Dwyer, Rashmi Kumar
JournalJournal of the National Comprehensive Cancer Network : JNCCN (J Natl Compr Canc Netw) Vol. 13 Issue 6 Pg. 772-99 (Jun 2015) ISSN: 1540-1413 [Electronic] United States
PMID26085393 (Publication Type: Journal Article)
CopyrightCopyright © 2015 by the National Comprehensive Cancer Network.
Topics
  • Combined Modality Therapy
  • Disease Management
  • Humans
  • Male
  • Neoplasm Staging
  • Practice Guidelines as Topic
  • Seminoma (diagnosis, therapy)
  • Testicular Neoplasms (diagnosis, therapy)

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