Involvement of Mζ-Like Protein Kinase in the Mechanisms of Conditioned Food Aversion Memory Reconsolidation in the Helix lucorum.

Abstract

We studied the involvement of Mζ-like protein kinase (PKMζ) into mechanisms of conditioned food aversion memory reconsolidation in Helix lucorum. Injections PKMζ inhibitor ZIP in a dose of 5 mg/kg on day 2 or 10 after learning led to memory impairment and amnesia development. Injections of the inhibitor in doses of 1.5 or 2.5 mg/kg had no effect. Repeated training on day 11 after induction of amnesia resulted in the formation of memory on the same type of food aversion similar to first training. The number of combinations of conditional (food) and reinforcing (electrical shock) stimuli was similar during initial and repeated training. We hypothesize that the inhibition of Mζ-like protein kinase erases the memory trace and a new memory is formed during repeated training.

• Authors: S V Solntseva, S A Kozyrev, V P Nikitin
• Journal: Bulletin of experimental biology and medicine (Bull Exp Biol Med) Vol. 159 Issue 2 Pg. 192-6 (Jun 2015) ISSN: 1573-8221 [Electronic] United States
• PMID: 26085351 (Publication Type: Journal Article)

Chemical References

• protein kinase C zeta
• Protein Kinase C

Topics

• Analysis of Variance
• Animals
• Avoidance Learning (physiology)
• Conditioning, Classical (physiology)
• Electric Stimulation
• Feeding Behavior (physiology)
• Helix, Snails (metabolism, physiology)
• Memory Consolidation (physiology)
• Memory, Long-Term (physiology)
• Protein Kinase C (metabolism)