Clinical impact of (11)C-Pittsburgh compound-B positron emission tomography carried out in addition to magnetic resonance imaging and single-photon emission computed tomography on the diagnosis of Alzheimer's disease in patients with dementia and mild cognitive impairment.

Abstract

AIMS:

The purpose of this study was to evaluate the clinical impact of addition of [(11)C]Pittsburgh compound-B positron emission tomography ((11)C-PiB PET) on routine clinical diagnosis of Alzheimer's disease (AD) dementia and mild cognitive impairment (MCI), and to assess diagnostic agreement between clinical criteria and research criteria of the National Institute on Aging-Alzheimer's Association.

METHODS:

The diagnosis in 85 patients was made according to clinical criteria. Imaging examinations, including both magnetic resonance imaging and single-photon emission computed tomography/computed tomography to identify neuronal injury (NI), and (11)C-PiB PET to identify amyloid were performed, and all subjects were re-categorized according to the research criteria.

RESULTS:

Among 40 patients with probable AD dementia (ProAD), 37 were NI-positive, 29 were (11)C-PiB-positive, and 27 who were both NI- and (11C-PiB-positive were categorized as having 'ProAD dementia with a high level of evidence of the AD pathophysiological process'. Among 20 patients with possible AD dementia (PosAD), 17 were NI-positive, and six who were both NI- and (11)C-PiB-positive were categorized as having 'PosAD with evidence of the AD pathophysiological process'. Among 25 patients with MCI, 18 were NI-positive, 13 were (11)C-PiB-positive, and 10 who were both NI- and (11)C-PiB-positive were categorized as having 'MCI due to AD-high likelihood'.

CONCLUSIONS:

Diagnostic concordance between clinical criteria and research criteria may not be high in this study. (11)C-PiB PET may be of value in making the diagnosis of dementia and MCI in cases with high diagnostic uncertainty.

• Authors: Yoshie Omachi, Kimiteru Ito, Kunimasa Arima, Hiroshi Matsuda, Yasuhiro Nakata, Masuhiro Sakata, Noriko Sato, Kazuyuki Nakagome, Nobutaka Motohashi
• Journal: Psychiatry and clinical neurosciences (Psychiatry Clin Neurosci) Vol. 69 Issue 12 Pg. 741-51 (Dec 2015) ISSN: 1440-1819 [Electronic] Australia
• PMID: 26085054 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2015 The Authors. Psychiatry and Clinical Neurosciences © 2015 Japanese Society of Psychiatry and Neurology.

Chemical References

• 2-(4'-(methylamino)phenyl)-6-hydroxybenzothiazole
• Amyloid
• Aniline Compounds
• Benzothiazoles
• Carbon Radioisotopes
• Thiazoles

Topics

• Aged
• Aged, 80 and over
• Alzheimer Disease (diagnosis, diagnostic imaging)
• Amyloid (metabolism)
• Aniline Compounds
• Benzothiazoles
• Brain (diagnostic imaging, metabolism, pathology)
• Carbon Radioisotopes
• Cognitive Dysfunction (diagnosis, diagnostic imaging)
• Dementia (diagnosis, diagnostic imaging)
• Female
• Humans
• Magnetic Resonance Imaging
• Male
• Middle Aged
• Multimodal Imaging
• Positron-Emission Tomography
• Thiazoles
• Tomography, Emission-Computed, Single-Photon
• Tomography, X-Ray Computed