Comparison of the analgesic effects of paracetamol and tramadol in lumbar disc surgery.

Abstract

BACKGROUND/AIM:

To compare the postoperative analgesic efficacy and side effects of paracetamol and tramadol in patients undergoing lumbar disc surgery.

MATERIALS AND METHODS:

Group P (paracetamol group) was given 1 g of paracetamol intravenously 30 min before the end of the operation and 1 g each day at 6-h intervals. Group T (tramadol group) was given 1.5 mg/kg of tramadol as a loading dose and patient-controlled analgesia for 1 day. Hemodynamic parameters, modified Aldrete score, Ramsay sedation scale score, patient satisfaction scale (PSS) score, visual analog scale (VAS) score, nausea/vomiting scale score, and additional analgesic needs/times were recorded.

RESULTS:

PSS scores were significantly higher in Group T (P < 0.05). The total analgesic consumption was significantly higher in Group P. There were no significant differences in the VAS scores at any time points. Twenty-one patients in Group P and 8 patients in Group T needed additional analgesia (P < 0.05). The first additional analgesic time was earlier in Group P, and pain was more evident at the 15th minute and at hours 2 and 6 (P < 0.05).

CONCLUSION:

Paracetamol alone was not able to provide effective analgesia. Tramadol was more effective in the treatment of postoperative pain after lumbar disc surgery.

• Authors: Mehmet Ziya Yilmaz, Bahriye Binnur Sarihasan, Ebru Kelsaka, Nilay Taş, Aysun Çaglar Torun, Ersin Köksal, Enis Kuruoğlu
• Journal: Turkish journal of medical sciences (Turk J Med Sci) Vol. 45 Issue 2 Pg. 438-42 ( 2015) ISSN: 1300-0144 [Print] Turkey
• PMID: 26084138 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Analgesics
• Acetaminophen
• Tramadol

Topics

• Acetaminophen (administration & dosage, adverse effects)
• Adult
• Analgesics (administration & dosage, adverse effects)
• Drug Monitoring
• Female
• Humans
• Lumbar Vertebrae (surgery)
• Male
• Middle Aged
• Orthopedic Procedures (adverse effects, methods)
• Pain Management (methods)
• Pain Measurement
• Pain, Postoperative (diagnosis, drug therapy)
• Spinal Diseases (surgery)
• Tramadol (administration & dosage, adverse effects)
• Treatment Outcome