Role of chemotherapy in the treatment of metastatic castration-resistant prostate cancer patients who have progressed after abiraterone acetate.

Abstract

Abiraterone acetate is a novel irreversible inhibitor of CYP17 that was recently approved for men with post-chemotherapy or chemo-naive castration-resistant prostate cancer. Unfortunately, this agent is not curative, and patients often ultimately develop resistance. However, men who progress after treatment with this new hormonal agent may be considered for another line of chemotherapy-based treatment. In 2004, docetaxel (D) and prednisone were found to improve survival compared with older regimens. More recently, cabazitaxel (C), a novel taxane chemotherapy, has been found to prolong survival in patients who exhibit disease progression during or after D chemotherapy. Here, we review the first clinical studies in which castration-resistant prostate cancer patients received chemotherapy with D or C after progression during abiraterone acetate treatment.

• Authors: Roberto Petrioli, Edoardo Francini, Letizia Laera, Anna Ida Fiaschi, Roberto Ponchietti, Giandomenico Roviello
• Journal: Cancer chemotherapy and pharmacology (Cancer Chemother Pharmacol) Vol. 76 Issue 3 Pg. 439-45 (Sep 2015) ISSN: 1432-0843 [Electronic] Germany
• PMID: 26082421 (Publication Type: Journal Article, Review)

Chemical References

• Cytochrome P-450 Enzyme Inhibitors
• Taxoids
• Docetaxel
• cabazitaxel
• Abiraterone Acetate

Topics

• Abiraterone Acetate (administration & dosage, therapeutic use)
• Adult
• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Cytochrome P-450 Enzyme Inhibitors (administration & dosage, therapeutic use)
• Docetaxel
• Humans
• Male
• Neoplasm Metastasis
• Prostatic Neoplasms, Castration-Resistant (drug therapy)
• Taxoids (therapeutic use)
• Young Adult