Circumsporozoite protein as a potential target for antimalarials.

Abstract

Since the discovery of circumsporozoite protein (CSP), a major sporozoite surface antigen, by Ruth Nussenzweig and Victor Nussenzweig in the early 1980s, the role of CSP in protection against malaria has been extensively investigated. Several monoclonal antibodies against CSP have been generated to date, with some of them mediating antimalarial protection upon passive transfer into animals. Genetically engineered transgenic mosquitoes producing the anti-CSP antibody have recently been generated to reduce malarial transmission. A monoclonal anti-CSP antibody was produced in mice by adeno-associated virus vector, which protected them from malaria. Phase III trials with RTS,S vaccine that targets CSP of Plasmodium falciparum have shown modest efficacy. Polyclonal anti-CSP antibodies derived from children who received the RTS,S vaccine failed to block malarial transmission through mosquitoes, but passive transfer of monoclonal antibodies raised from RTS,S-vaccinated recipient conferred protection against malaria in mice. Taken together, these findings may imply CSP as an antimalarial target.

• Authors: Cristina Fernández-Arias, Sara Mashoof, Jing Huang, Moriya Tsuji
• Journal: Expert review of anti-infective therapy (Expert Rev Anti Infect Ther) Vol. 13 Issue 8 Pg. 923-6 (Aug 2015) ISSN: 1744-8336 [Electronic] England
• PMID: 26081442 (Publication Type: Editorial, Research Support, N.I.H., Extramural)

Chemical References

• Antibodies, Protozoan
• Antimalarials
• Malaria Vaccines
• Protozoan Proteins
• circumsporozoite protein, Protozoan

Topics

• Animals
• Antibodies, Protozoan (metabolism)
• Antimalarials (metabolism)
• Humans
• Immunization, Passive
• Malaria Vaccines (immunology)
• Malaria, Falciparum (immunology, prevention & control, transmission)
• Plasmodium falciparum (immunology)
• Protozoan Proteins (antagonists & inhibitors, immunology, metabolism)