Chemopreventive Effect of Cardamom (Elettaria cardamomum L.) Against Benzo(α)Pyrene-Induced Forestomach Papillomagenesis in Swiss Albino Mice.

Abstract

Prevention of cancer through dietary intervention has recently gained significant recognition. Cardamom (Elettaria cardamomum), a dietary phytoproduct, is a popular spice that is regularly used as a flavoring agent in various cuisines, and is much valued for its medicinal properties. In the present study, the cancer chemopreventive potential of cardamom was investigated against benzo(α)pyrene [B(α)P]-induced forestomach papillomagenesis in mice. Results showed that treatment with cardamom [(B(α)P + cardamom] reduced tumor incidence and multiplicity significantly (P<0.001) by 41.67% and 74.55%, respectively, compared to that of the B(α)P control group. Biochemical assays revealed a significant enhancement in the hepatic activities of glutathione-S-transferases (P<0.01), superoxide dismutase (P<0.01), glutathione peroxidase (P<0.001), and catalase (P<0.001) in mice treated with cardamom compared with the control. Furthermore, the nonenzymatic antioxidant glutathione was significantly (P<0.001) increased in the cardamom-treated group, whereas the lipid peroxidation level along with lactate dehydrogenase activity exhibited a significant (P<0.01) reduction with cardamom treatment compared to the control. These results suggest that cardamom has the potential to become a pivotal chemopreventive agent against forestomach cancer.

• Authors: Samir Qiblawi, Sasikumar Dhanarasu, Mo'ez Al-Islam Faris
• Journal: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer (J Environ Pathol Toxicol Oncol) Vol. 34 Issue 2 Pg. 95-104 ( 2015) ISSN: 2162-6537 [Electronic] United States
• PMID: 26081028 (Publication Type: Controlled Clinical Trial, Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Antioxidants
• Benzo(a)pyrene
• L-Lactate Dehydrogenase
• Glutathione

Topics

• Animals
• Antineoplastic Agents, Phytogenic (pharmacology)
• Antioxidants (metabolism)
• Benzo(a)pyrene (toxicity)
• Elettaria (chemistry)
• Glutathione (metabolism)
• L-Lactate Dehydrogenase (metabolism)
• Lipid Peroxidation (drug effects)
• Liver (drug effects, enzymology)
• Male
• Mice
• Papilloma (chemically induced, drug therapy)
• Phytotherapy
• Stomach Neoplasms (chemically induced, drug therapy)