Abstract | CONTEXT: Currently no direct evidence links in utero dichlorodiphenyltrichloroethane ( DDT) exposure to human breast cancer. However, in utero exposure to another xenoestrogen, diethylstilbestrol, predicts an increased breast cancer risk. If this finding extends to DDT, it could have far-reaching consequences. Many women were heavily exposed in utero during widespread DDT use in the 1960s. They are now reaching the age of heightened breast cancer risk. DDT exposure persists and use continues in Africa and Asia without clear knowledge of the consequences for the next generation. HYPOTHESIS: DESIGN: This was a case-control study nested in a prospective 54-year follow-up of 9300 daughters in the Child Health and Development Studies pregnancy cohort (n = 118 breast cancer cases, diagnosed by age 52 y and 354 controls matched on birth year). SETTING AND PARTICIPANTS: Kaiser Foundation Health Plan members who received obstetric care in Alameda County, California, from 1959 to 1967, and their adult daughters participated in the study. MAIN OUTCOME MEASURE: Daughters' breast cancer diagnosed by age 52 years as of 2012 was measured. RESULTS: Maternal o,p'-DDT predicted daughters' breast cancer (odds ratio fourth quartile vs first = 3.7, 95% confidence interval 1.5-9.0). Mothers' lipids, weight, race, age, and breast cancer history did not explain the findings. CONCLUSIONS: This prospective human study links measured DDT exposure in utero to risk of breast cancer. Experimental studies are essential to confirm results and discover causal mechanisms. Findings support classification of DDT as an endocrine disruptor, a predictor of breast cancer, and a marker of high risk.
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Authors | Barbara A Cohn, Michele La Merrill, Nickilou Y Krigbaum, Gregory Yeh, June-Soo Park, Lauren Zimmermann, Piera M Cirillo |
Journal | The Journal of clinical endocrinology and metabolism
(J Clin Endocrinol Metab)
Vol. 100
Issue 8
Pg. 2865-72
(Aug 2015)
ISSN: 1945-7197 [Electronic] United States |
PMID | 26079774
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
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Topics |
- Adult
- Adult Children
(statistics & numerical data)
- Breast Neoplasms
(chemically induced, diagnosis, epidemiology, pathology)
- Case-Control Studies
- DDT
(blood, toxicity)
- Environmental Exposure
(adverse effects, statistics & numerical data)
- Female
- Follow-Up Studies
- Humans
- Infant, Newborn
- Middle Aged
- Neoplasm Staging
- Pregnancy
- Prenatal Exposure Delayed Effects
(blood, chemically induced, epidemiology)
- Prognosis
- Young Adult
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