Peripheral blood stem cell mobilization failure.

Abstract

Autologous hematopoietic stem cell transplantation (HSCT) is an important and often life saving treatment for many hematological malignancies and selected solid tumors. To rescue hematopoiesis after high-dose chemotherapy in autologous HSCT depends on maintaining sufficient stem cells. Hematopoietic stem cells and progenitor cells expressing CD34 in the BM are mobilized into the circulation with granulocyte-colony stimulating factor ± chemotherapy prior to autologous HSCT. One of the most important factors for success of autologous HSCT is hematopoietic stem cell (HSC) count. Minimum threshold for the engraftment of hematopoietic cells is accepted as 2 × 10(6) CD34 + cells/kg especially for platelet engraftment. Below this level it is defined as stem cell mobilization failure. There are several factors affecting stem cell mobilization: prior chemotherapy (such as fludarabine, melphalan, lenalidomide) and radiotherapy, age, type of disease, bone marrow cellularity. We tried to summarize the reasons of peripheral stem cell mobilization failure.

• Authors: Fatih Kurnaz, Leylagül Kaynar
• Journal: Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis (Transfus Apher Sci) Vol. 53 Issue 1 Pg. 3-7 (Aug 2015) ISSN: 1473-0502 [Print] England
• PMID: 26074051 (Publication Type: Journal Article)
• Copyright: Copyright © 2015 Elsevier Ltd. All rights reserved.

Chemical References

• Granulocyte Colony-Stimulating Factor

Topics

• Autografts
• Bone Marrow (metabolism)
• Female
• Granulocyte Colony-Stimulating Factor (metabolism)
• Hematopoietic Stem Cell Mobilization (adverse effects)
• Hematopoietic Stem Cells (metabolism)
• Humans
• Male
• Peripheral Blood Stem Cell Transplantation