Abstract | OBJECTIVES: METHODS: Sixty-four healthy volunteers with proven ovulatory cycles were randomised and treated with either the drospirenone-only or the desogestrel-only pill during two 28-day cycles. Follicular diameter, endometrial thickness, and serum estradiol (E2) and progesterone concentrations were measured and Hoogland scores were determined. Additionally, cervical mucus scores, bleeding and return of ovulation were assessed. RESULTS: Both treatments effectively inhibited ovulation. Follicular diameter, E2 levels and Hoogland scores were equal, demonstrating efficient ovarian suppression. One subject in each group had a Hoogland score of 6, but the criteria for normal luteal activity were not fulfilled. In both groups, ovulation did not occur before day 9 of the post-treatment cycle. Cervical mucus permeability was suppressed in both groups. The median number of bleeding and spotting days was lower in the drospirenone group. CONCLUSIONS:
|
Authors | Ingrid J M Duijkers, Doris Heger-Mahn, Dominique Drouin, Sven Skouby |
Journal | The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception
(Eur J Contracept Reprod Health Care)
Vol. 20
Issue 6
Pg. 419-27
( 2015)
ISSN: 1473-0782 [Electronic] England |
PMID | 26073333
(Publication Type: Clinical Trial, Phase II, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
|
Chemical References |
- Androstenes
- Contraceptives, Oral, Synthetic
- Progesterone
- Estradiol
- Desogestrel
- drospirenone
|
Topics |
- Adult
- Androstenes
(chemistry, pharmacology)
- Cervix Mucus
(drug effects, metabolism)
- Contraceptives, Oral, Synthetic
(chemistry, pharmacology)
- Desogestrel
(chemistry, pharmacology)
- Endometrium
(anatomy & histology, drug effects)
- Estradiol
(blood)
- Female
- Healthy Volunteers
- Humans
- Metrorrhagia
(chemically induced)
- Ovarian Follicle
(anatomy & histology, drug effects)
- Ovulation Inhibition
(drug effects)
- Permeability
(drug effects)
- Progesterone
(blood)
- Young Adult
|