Abstract | BACKGROUND: METHODS: Several databases were searched from inception to December 31 2013 for trials comparing photodynamic therapy+stent vs. stent-only or other treatments for cholangiocarcinoma. The outcomes of interest included patient survival, the changes of serum bilirubin levels, the quality of life (Karnofsky performance status), and adverse events. The hazard ratios (HR) were extracted from the survival curves using Tierney's Method. LnHR and its variance were pooled using an inverse variance-weighted average. Inconsistency was quantified using I(2) statistics. RESULTS: In all, 8 trials comparing PDT+stent with other therapeutic methods were selected. We made a meta-analysis based on the 7 trials, which compared the result of PDT+stent and the stent-only group. HR summarizes the survival for the two groups. Overall survival was significantly better in patients who received photodynamic therapy than those who did not [HR=0.49, 95% confidence interval (CI), 0.33∼0.73, P=0.0005]. Among the 8 trials (642 subjects), 5 assessed the changes of serum bilirubin levels, and/or Karnofsky performance status, as other indications for improvement. In all, the incidence for phototoxic reaction is 11.11%. The incidence for other events in photodynamic therapy and the stent-only group was 13.64% and 12.79%, respectively. CONCLUSION:
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Authors | Yi Lu, Lei Liu, Jia-chuan Wu, Li-Ke Bie, Biao Gong |
Journal | Clinics and research in hepatology and gastroenterology
(Clin Res Hepatol Gastroenterol)
Vol. 39
Issue 6
Pg. 718-24
(Dec 2015)
ISSN: 2210-741X [Electronic] France |
PMID | 26070572
(Publication Type: Journal Article, Meta-Analysis)
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Copyright | Copyright © 2015. Published by Elsevier Masson SAS. |
Topics |
- Bile Duct Neoplasms
(drug therapy)
- Cholangiocarcinoma
(drug therapy)
- Humans
- Photochemotherapy
(adverse effects)
- Treatment Outcome
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