Abstract | PURPOSE: Vascular access (VA) devices may contribute to chronic inflammation in hemodialysis (HD). Pentraxin 3 (PTX3) is a recently discovered acute phase protein that responds more rapidly than other inflammatory markers. This study compared PTX3 and other markers between HD patients and healthy controls. METHODS: RESULTS: PTX levels were highest in HD patients with TPC, intermediated in HD patients with AVF and lowest in healthy controls (5.2 + 2.4 vs. 3.1 + 1.3 vs. 1.8 + 0.7, p<0.001 for all comparisons). PTX3 levels correlated strongly to hs-CRP (r = 0.857) and moderately to TNF-α, NLR, ferritin and total neutrophil count. PTX3 and albumin levels had a negative correlation. PTX3 levels were higher in patients with 8 months of TPC than those with 7 months or less. CONCLUSIONS: PTX3 levels are significantly elevated in all patients on HD, but presence and extended duration of TPC are associated with incrementally higher levels of PTX3 and other inflammatory markers. PTX3 and NLR may be useful in assessing chronic inflammatory states in HD.
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Authors | Irem Pembegul Yigit, Ayhan Dogukan, Hulya Taskapan, Melda Comert, Necip Ilhan, Ramazan Ulu, Bilge Aygen |
Journal | The journal of vascular access
(J Vasc Access)
2015 Sep-Oct
Vol. 16
Issue 5
Pg. 377-81
ISSN: 1724-6032 [Electronic] United States |
PMID | 26070095
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers
- Inflammation Mediators
- Serum Amyloid P-Component
- PTX3 protein
- C-Reactive Protein
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Topics |
- Adult
- Aged
- Arteriovenous Shunt, Surgical
- Biomarkers
(blood)
- C-Reactive Protein
(metabolism)
- Case-Control Studies
- Catheterization
(adverse effects, instrumentation)
- Catheters, Indwelling
- Equipment Design
- Female
- Humans
- Inflammation
(blood, diagnosis, etiology)
- Inflammation Mediators
(blood)
- Male
- Middle Aged
- Renal Dialysis
- Risk Factors
- Serum Amyloid P-Component
(metabolism)
- Time Factors
- Treatment Outcome
- Up-Regulation
- Vascular Access Devices
- Young Adult
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