NPM1 activates metabolic changes by inhibiting FBP1 while promoting the tumorigenicity of pancreatic cancer cells.

Abstract	The nucleophosmin (NPM1) activates cancer development and progression in many malignant tumors. However, the regulatory role and underlying mechanisms of NPM1 in pancreatic cancer are unknown. In this study, we showed that NPM1 was up-regulated in PDAC, which indicated a poor prognosis. We also identified NPM1 could stimulate aerobic glycolysis and repress fructose-1, 6-bisphosphatase 1 (FBP1) in pancreatic cancer cells. Restoring FBP1 expression partially reversed the tumor-promoting effects of NPM1, while the loss of FBP1 in PDAC tissues was indicative of a poorer prognosis. In sum, NPM1 promotes aerobic glycolysis and tumor progression in patients with pancreatic cancer by inhibiting FBP1.
Authors	Yi Zhu, Minmin Shi, Hao Chen, Jiangning Gu, Jiaqiang Zhang, Baiyong Shen, Xiaxing Deng, Junjie Xie, Xi Zhan, Chenghong Peng
Journal	Oncotarget (Oncotarget) Vol. 6 Issue 25 Pg. 21443-51 (Aug 28 2015) ISSN: 1949-2553 [Electronic] United States
PMID	26068981 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Biomarkers, Tumor DNA-Binding Proteins FUBP1 protein, human Lactates NPM1 protein, human Npm1 protein, mouse Nuclear Proteins RNA-Binding Proteins Nucleophosmin DNA Helicases Glucose
Topics	Animals Biomarkers, Tumor (metabolism) Carcinoma, Pancreatic Ductal (metabolism, pathology) Cell Line, Tumor DNA Helicases (antagonists & inhibitors, metabolism) DNA-Binding Proteins (antagonists & inhibitors, metabolism) Disease Progression Gene Expression Profiling Gene Expression Regulation, Neoplastic Glucose (chemistry) Glycolysis HEK293 Cells Humans Immunohistochemistry Lactates (chemistry) Male Mice Mice, Nude Neoplasm Transplantation Nuclear Proteins (metabolism) Nucleophosmin Pancreatic Neoplasms (metabolism, pathology) Prognosis RNA-Binding Proteins Tissue Array Analysis Up-Regulation

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