Abstract | SIGNIFICANCE: RECENT ADVANCES: High-mobility group box 1 ( HMGB1), a nuclear DNA-binding protein, was recently discovered to function as a damage-associated molecular pattern molecule (DAMP) that initiates the innate immune responses. These findings lead to the understanding that HMGB1 plays a critical role in the inflammatory response in the pathogenesis of CVD. CRITICAL ISSUES: FUTURE DIRECTIONS: A key focus for future researches on HMGB1 location, structure, modification, and signaling will reveal HMGB1's multiple functions and discover a targeted therapy that can eliminate HMGB1-mediated inflammation without interfering with adaptive immune responses.
|
Authors | Jingjing Cai, Juan Wen, Eileen Bauer, Hua Zhong, Hong Yuan, Alex F Chen |
Journal | Antioxidants & redox signaling
(Antioxid Redox Signal)
Vol. 23
Issue 17
Pg. 1351-69
(Dec 10 2015)
ISSN: 1557-7716 [Electronic] United States |
PMID | 26066838
(Publication Type: Journal Article, Review)
|
Chemical References |
- HMGB1 Protein
- HMGB1 protein, human
|
Topics |
- Adaptive Immunity
- Cardiovascular Diseases
(immunology, metabolism)
- Cardiovascular System
(immunology, metabolism)
- Coronary Artery Disease
(immunology, metabolism)
- HMGB1 Protein
(metabolism)
- Humans
- Hypertension, Pulmonary
(immunology, metabolism)
- Immunity, Innate
- Peripheral Arterial Disease
(immunology, metabolism)
|