New Zealand white rabbits (N = 4) were challenged with the local strain of Trypanosoma evansi. Each rabbit was infected with 5 × 10(5) trypanosomes subcutaneously. The
infection was characterized by intermittent
pyrexia, undulating parasitaemia,
anorexia and
emaciation. The infected rabbits were examined daily for development of clinical signs and
infection status by wet blood-films made from the ear veins. Thick and thin blood smears were also examined daily until the end of the experiment for description of blood cells. Differential leukocyte count (DLC) was also done. The parasite was observed in the blood during the acute phase only.
Leukocytosis in the acute phase followed by
leukopenia during the chronic phase was recognized. Haematological studies revealed reduced TEC, Hb and PCV. The main changes in the erythrocytes were macrocytes, hypochromic cells, Howell-Jolly bodies, target cells, stomatocytes and burr cells. Serum chemistry revealed
hypoproteinemia, hypocholesterolaemia,
hypoglycemia,
hyperbilirubinemia, elevated
creatinine, BUN, increased AST and ALT.