Abstract | BACKGROUND: METHODS: High-performance liquid chromatography/tandem mass spectrometry was used to quantify levels of 15 individual estrogens and estrogen metabolites (EM) among 587 premenopausal women in the Nurses' Health Study II with mid-luteal phase urine samples and caffeine, coffee, and/or tea intakes from self-reported food frequency questionnaires. Multivariate linear mixed models were used to estimate geometric means of individual EM, pathways, and ratios by intake categories, and P values for tests of linear trend. RESULTS: Compared with women in the lowest quartile of caffeine consumption, those in the top quartile had higher urinary concentrations of 16α-hydroxyestrone (28% difference; Ptrend = 0.01) and 16-epiestriol (13% difference; Ptrend = 0.04), and a decreased parent estrogens/2-, 4-, 16-pathway ratio (Ptrend = 0.03). Coffee intake was associated with higher 2-catechols, including 2-hydroxyestradiol (57% difference, ≥4 cups/day vs. ≤6 cups/week; Ptrend = 0.001) and 2-hydroxyestrone (52% difference; Ptrend = 0.001), and several ratio measures. Decaffeinated coffee was not associated with 2-pathway metabolism, but women in the highest (vs. lowest) category of intake (≥2 cups/day vs. ≤1-3 cups/month) had significantly lower levels of two 16-pathway metabolites, estriol (25% difference; Ptrend = 0.01) and 17-epiestriol (48% difference; Ptrend = 0.0004). Tea intake was positively associated with 17-epiestriol (52% difference; Ptrend = 0.01). CONCLUSION: IMPACT:
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Authors | Julia S Sisti, Susan E Hankinson, Neil E Caporaso, Fangyi Gu, Rulla M Tamimi, Bernard Rosner, Xia Xu, Regina Ziegler, A Heather Eliassen |
Journal | Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
(Cancer Epidemiol Biomarkers Prev)
Vol. 24
Issue 8
Pg. 1174-83
(Aug 2015)
ISSN: 1538-7755 [Electronic] United States |
PMID | 26063478
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural)
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Copyright | ©2015 American Association for Cancer Research. |
Chemical References |
- Coffee
- Estrogens
- Tea
- Caffeine
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Topics |
- Adult
- Caffeine
(chemistry)
- Chromatography, Liquid
(methods)
- Coffee
(chemistry)
- Cohort Studies
- Estrogens
(urine)
- Female
- Humans
- Middle Aged
- Premenopause
(urine)
- Prospective Studies
- Tandem Mass Spectrometry
(methods)
- Tea
(chemistry)
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